NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Expanding Horizons: Robotic Minimally Invasive Direct Coronary Artery Bypass with Left Atrial Appendage Exclusion - A Step Forward in Minimally Invasive Cardiac Surgery. [PDF]
Braz J Cardiovasc SurgSaad A.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Therapy-induced androgen receptor signaling as a candidate upstream driver of B7-H3-linked immune exclusion in melanoma: mechanisms and translational opportunities. [PDF]
Front Med (Lausanne)Mansini AP, Hyngstrom JR, Amber KT.
europepmc +1 more source
Causal exclusion without explanatory exclusion
, 2002 The causal/explanatory exclusion argument is one of the principal weapons against the possibility of mental causes/explanations having genuine causal/explanatory have genuine casual/explanatory power. I argue that the causal and the explanatory versions of the exclusion argument should be distinguished.
openaire +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The impact of social exclusion on malevolent creativity in college students: the mediating role of aggression and the moderating effect of team sports participation-evidence from universities in Shanghai. [PDF]
Front PsycholShi J, Qiu H, Li J, Liu B.
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
How Many Anxious Kids in Community Mental Health Would Be Eligible for an RCT? And Does It Matter? Insights from a Naturalistic Sample and a Non-Systematic Review. [PDF]
Children (Basel)English AC +3 more
europepmc +1 more source