Results 71 to 80 of about 2,425,360 (253)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Neural network as a mirror of social attitudes: analysis of distortions in generative images
Цифровая социологияThe article is devoted to the consideration of neural network generative technologies as a marker of social stereotypes and attitudes. The aim of the research – approbation of generative artificial intelligence (hereinafter referred to as AI) as a method
A. G. Tertyshnikova +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Social exclusion mobility in Spain, 1994-2000 [PDF]
Social exclusion can be defined as a process leading to a state of multiple functioning deprivations. Cross-sectional headcount ratios of social exclusion may overstate the extent of the problem if most individuals do not remain in the same state in ...
Ambra Poggi
core
The social exclusion debate : strategies, controversies and dilemmas [PDF]
, 2005 This paper explores the UK government's approach to combating social exclusion since 1997. It considers the philosophy and political economy underpinning New Labour policy, and explains the economic and social policy prescriptions that follow from these ...
Davies, Jonathan S., Davies, Jonathan
core +1 more source
This paper critically examines the multidimensional mechanisms of social exclusion faced by rural-to-urban migrants in China since the 1978 Reform and Opening-up process, and shows how the interplay of institutional design, market logic and cultural ...
Yang, Xinxian
core +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Social Exclusion: the Concept and Application to Developing Countries [PDF]
The feasibility of operationalisation of the 'social exclusion' concept in developing countries is investigated in this paper. The origins of the approach in relation to the welfare state and unemployment status and its spread in Western Europe and ...
Ruhi Saith
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source