Results 71 to 80 of about 169,851 (235)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Inclusive governance in non-profit organisations [PDF]
, 2015 The study of private non-profit enterprises that offer general interest services is only at the start. The understanding of existing organisations resists an inclusive, public interest view of governance.
Borzaga, Carlo, Sacchetti, Silvia
core
Search for $C=+$ charmonium and bottomonium states in $e^+e^-\to \gamma+ X$ at B factories
, 2009 We study the production of $C=+$ charmonium states $X$ in $e^+e^-\to \gamma + X$ at B factories with $X=\eta_c(nS)$ (n=1,2,3), $\chi_{cJ}(mP)$ (m=1,2), and $^1D_2(1D)$. In the S and P wave case, contributions of tree-QED with one-loop QCD corrections are
Dan Li +3 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Rare top quark production and decays at ATLAS and CMS
, 2019 The most recent studies in the top quark sector are reviewed with the focus on the rare production mechanisms and suppressed decays. The experimental results obtained with the ATLAS and CMS detectors in proton-proton collisions at the center-of-mass ...
Skovpen, Kirill
core
Making mathematics inclusive: interpreting the meaning of classroom activity. [PDF]
, 2003 The article discusses the view of the author on using hermeneutics. According to the author, hermeneutics is the theory of interpretation which is categorized in forms including conservative hermeneutics, moderate hermeneutics, and radical hermeneutics ...
Brown, Tony
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Observations of Chiral Odd GPDs and their Implications
, 2013 Our original suggestion to investigate exclusive $\pi^0$ electroproduction as a method for extracting the tensor charge, transversity, and other quantities related to chiral odd generalized parton distributions from cross section and asymmetry data is ...
Goldstein, Gary R. +2 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source