Results 71 to 80 of about 3,910 (241)
, 2019 Homosexuality, Transidentity, and Islam builds on existing scholarship in a variety of disciplines on the topic of gender and sexuality in Islam. In this concise-yet comprehensive-book, Ludovic-Mohamed Zahed systematically analyses the entirety of ...
Bharat, Adi, Zahed, Ludovic-Mohamed
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Islam i chrześcijaństwo w perspektywie pluralizmu religijnego Johna Hicka [PDF]
, 2011 Damian Kokoć – ISLAM AND CHRISTIANITY IN THE PERSPECTIVE OF JOHN HICK’S RELIGIOUS PLURALISM John Hick is one of the leading representatives of religious pluralism.
Kokoć, Damian
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
A Study of Preschool Children's Reasoning with an Exclusive Interpretation of "Or"
, 2005 vii, 49 p.There is a debate between psycholinguists and logicians about whether people use an exclusive or interpretation (XOR) or an inclusive or interpretation (lOR), and when an understanding of each emerges in development.
Jorgensen, Katia E.
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Islamic Education and Pluralism: An Overview of Multicultural Education Management [PDF]
Background: Pluralism and multiculturalism are critical issues in the context of global education, particularly in increasingly diverse societies in terms of culture, religion, and ethnicity. Islamic education, as a value-based spiritual education system,
Anwar, Khairil, Fauzi, Rahmat
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source