Results 61 to 70 of about 190,541 (353)

Patent and exclusivity status of essential medicines for non-communicable disease. [PDF]

PLoS ONE, 2012
OBJECTIVE: The threat of non-communicable diseases ("NCDs") is increasingly becoming a global health crisis and are pervasive in high, middle, and low-income populations resulting in an estimated 36 million deaths per year.
Tim K Mackey, Bryan A Liang
doaj   +1 more source

Discrete choice experiment to investigate preferences for incentives to promote antimicrobial research and development

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Without intervention, experts predict that antimicrobial resistance will rank among leading drivers of mortality by 2050. New drugs are desperately needed, but given the lengthy development timelines for antimicrobial research and ...
Leon Rohde, Elias Mossialos, Charlotte Beaudart, Angelika Joos, Inka Heikkinen, Silas Holland, Mickaël Hiligsmann   +6 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

(Dis)Abling church spaces: Walking the talk of inclusivity in Zimbabwe

HTS Teologiese Studies/Theological Studies
Since time immemorial, the Church has had much to say about people living with disabilities in and beyond its walls. Commendably, in Zimbabwe, the Church has established and supported schools for people with hearing, visual, physical and psychological ...
Kimion Tagwirei
doaj   +1 more source

Risk Assessment of Failures in Generic Drug Development and Approval Procedure under Competitive Generic Drug Therapy and Patent Challenge Exclusivities Provided by the United States Food and Drug Administration

Acta Marisiensis - Seria Medica, 2022
Objective: The United States Food and Drug Administration implemented two exclusivity programs Competitive generic therapy and Patent Challenge exclusivity to develop generic drugs, which provide a 180-day monopoly market for first generic applicants in ...
Reddy M Vivek, Ganesh GNK, Babu B, Jagadeesan Ramesh, MR Praharsh Kumar   +4 more
doaj   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Montreal exclusivity versus EU law [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2015
Current air law is a showcase of multilevel regulation. The rights and obligations of airlines and their passengers are governed both by the Montreal Convention and by EU Regulation 261/2004.
Đurđev Dušanka J.
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The Accessibility of the Late Medieval Goldsmith Guild of Bruges

Tijdschrift voor Sociale en Economische Geschiedenis, 2019
The aim of this article is twofold. First, it offers an analysis of heredity and exclusivity in Bruges' late medieval goldsmith guild on the basis of prosopographical research.
Silke Muylaert
doaj   +1 more source