Results 41 to 50 of about 22,706 (266)
SSRN Electronic Journal, 2005 In their influential paper, Aghion and Bolton (1987) argue that a buyer and a seller may agree on high liquidation damages in order to extract rents from future suppliers. As this may distort future trade, it may be socially wasteful. We argue that Aghion and Bolton's analysis of entry is incomplete in some respects, as there is only one potential ...
Moen, Espen R, Riis, Christian
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Illusion of Exclusivity [PDF]
European Journal of Philosophy, 2013 AbstractIt is widely held that when you are deliberating about whether to believe some propositionp, only considerations relevant to the truth ofpcan be taken into account as reasons bearing on whether to believepand motivate you accordingly. This thesis ofexclusivityhas significance for debates about the nature of belief, about control of belief, and ...
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
ReligionsAmong the most perplexing of John’s theological riddles is question of salvific universalism and particularity. John is both the greatest biblical source of Christian universalism and the greatest source of Christian exclusivity. After all, the Johannine
Paul N. Anderson
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
(Dis)Abling church spaces: Walking the talk of inclusivity in Zimbabwe
HTS Teologiese Studies/Theological StudiesSince time immemorial, the Church has had much to say about people living with disabilities in and beyond its walls. Commendably, in Zimbabwe, the Church has established and supported schools for people with hearing, visual, physical and psychological ...
Kimion Tagwirei
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Patent and exclusivity status of essential medicines for non-communicable disease. [PDF]
PLoS ONE, 2012 OBJECTIVE: The threat of non-communicable diseases ("NCDs") is increasingly becoming a global health crisis and are pervasive in high, middle, and low-income populations resulting in an estimated 36 million deaths per year.
Tim K Mackey, Bryan A Liang
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