Results 31 to 40 of about 22,706 (266)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
ErkenntnisAbstract We present a logic which deals with connexive exclusion. Exclusion (also called “co-implication”) is considered to be a propositional connective dual to the connective of implication. Similarly to implication, exclusion turns out to be non-connexive in both classical and intuitionistic logics, in the ...
Yaroslav Shramko, Heinrich Wansing
openaire +4 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Influence of Power Distance Beliefs and Advertising Appeal on Consumers’ Purchase Intentions
Journal of Theoretical and Applied Electronic Commerce ResearchThe global economic integration in the digital era, crafting marketing messages that resonate across diverse cultural landscapes poses a significant challenge for businesses.
Ruotong Feng +4 more
doaj +1 more source
HTS Teologiese Studies/Theological Studies, 2018 In this study, the development of faith communities is investigated in different texts and contexts. The socio-religious understanding of various communities, from the time of the Old Testament, to today, has the potential to provide an understanding of ...
Ananda Geyser-Fouche, Carli Fourie
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Frontiers in Psychology, 2021 The goal of this review is twofold: first to explore whether mutual exclusivity and functional fixedness overlap and what might be their respective specificities and second, to investigate whether mutual exclusivity as an inferential principle could be ...
Thuy Tuong Uyen Tran +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source