Results 51 to 60 of about 381,106 (267)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

فاعلية برنامج قائم علي فنيات التمثيل النفسـي المسـرحي لتنمية الوظائف التنفيذية لدي الأطفال المعاقين عقلياً القابلين للتعليم. [PDF]

مجلة الطفولة
يهدف البحث الحالي الي التحقق من فاعلية برنامج قائم علي فنيات التمثيل النفسي المسرحي لتنمية الوظائف التنفيذية لدي الأطفال المعاقين عقليا القابلين للتعليم.و تكونت عينة البحث من 10 أطفال من الذكور و الاناث و تتراوح أعمارهم ما بين (4-6) سنوات، تم استخدام ...
راشا محمد طه محمود طه
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Executive alumni networks: Catalysts or constraints for innovation in China’s listed firms?

Journal of Data and Information Science
Currently, different research conclusions exist about the relationship between relational capital and corporate innovation. The research aims to (1) reveal the actual relationship between executive alumni relations and firm innovation performance, (2 ...
Guo Jinzhong, Liu Jianan, Li Moxin, Liu Xiaoling, Liu Chengyong   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Executive Compensation

Foundations and Trends® in Finance, 2017
The optimal design of executive compensation is one of the primary issues in the area of corporate governance and has been investigated in considerable detail in the academic literature over the past three decades. The underlying assumption behind the design of optimal compensation schemes is that the executives of the firm have more information on the
openaire   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

A Common Structure for Factors that Enhance Synergy in Contractor Project Teams: Executive and Practitioner Perspectives

Buildings
Synergy in a contractor project team improves performance by integrating diverse knowledge and skills among team members, enabling the achievement of project objectives.
Jakrapong Pongpeng, Nareerat Ratanawimol
doaj   +1 more source

Grappling with the gods: Reflections for coaches of the narcissistic leader [PDF]

International Journal of Evidence Based Coaching and Mentoring, 2010
While the general research literature has addressed narcissistic behaviours in executive leaders, the effect of its presence on the success of the executive coaching process has not been explored. The predominance of narcissism in our executives, however,
Kerri S Kearney
doaj