Results 61 to 70 of about 984,116 (266)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Health Service Executive National Service Plan 2012
, 2012 Under the legislative framework of the Health Act, 2004, Section 31, the primary purpose of the annual HSE National Service Plan (NSP) is to set out how the Estimate (budget) allocated to the HSE will be spent in the given year on the type and volume of ...
Health Service Executive (HSE)
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Координирачки улоги на извршната власт како варијабли кои ги оцртуваат безбедносните релации во Република Македонија [PDF]
Bezbednosni Dijalozi, 2013 This paper counterpoises an analysis of the coordinating roles of the executive in the effectuation of the needed coordination of the security sector in the Republic of Macedonia.
Oliver BAKRESKI, Stojan Slaveski
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As câmaras municipais brasileiras: perfil de carreira e percepção sobre o processo decisório local
Opinião Pública, 2005 Neste artigo, o legislativo municipal é analisado a partir de dois eixos: (1) a ênfase em suas características nacionais e regionais, com base em dados sobre a composição social e político-partidária do legislativo municipal no Brasil, no período de 1996,
Maria Teresa Miceli Kerbauy
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Executive Board Meetings, 1921
, 1921 Digitized microfilm from American Library Association Minutes of Executive Board Meetings, Volume 2.Proceedings of the Executive Board meetings in April 2, June 20-26, and December 28-31 ...
Executive Board
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Cuestiones ConstitucionalesThe lawmaking process in Indonesia, as defined by the 1945 Constitution, features extensive presidential involvement in proposing bills, participating in deliberations, and enacting laws. This departs from most presidential systems, where the executive’s
A Rosyid Al Atok, Muhamad Sayuti Hassan
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