Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
ObjectiveThis study aimed to examine the relationship between physical activity and executive function in preschool children, with a particular focus on the mediating role of sleep problem.MethodsA total of 159 preschool children participated in this ...
Xiaolong Chen +6 more
doaj +1 more source
The association of specific executive functions and falls risk in people with mild cognitive impairment and early-stage dementia [PDF]
Background/Aims: Impairment in executive function is associated with a heightened risk for falls in people with mild cognitive impairment (MCI) and dementia.
Booth, Victoria +7 more
core +1 more source
The role of lipid metabolism in neuronal senescence
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Do executive function and family factors predict children’s preference for trendy over classic toys? An experimental investigation [PDF]
Margarita Gavrilova +2 more
openalex +1 more source
The effect of cycling on cognitive function and well-being in older adults [PDF]
It has been demonstrated that, on their own, both exercise and stimulation from the environment can improve cognitive function and well-being in older adults.
Beale, Nick +4 more
core +3 more sources
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
Executive functions in insight versus non-insight problem solving: an individual differences approach [PDF]
Original article can be found at: http://www.informaworld.com/smpp/title~content=t713685607~db=all Copyright Informa / Taylor and FrancisThis study investigated the roles of the executive functions of inhibition and switching and of verbal and visuo ...
Fioratou, E., Gilhooly, K.
core +2 more sources
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Effects of Information and Communication Technology Use on the Executive Function of Older Adults without Dementia: A Longitudinal Fixed-Effect Analysis [PDF]
Background Impaired executive function is common in older adults. This study examined the causal relationship between the use of information and communication technology (ICT) and executive function in older adults over time.
Hamin Lee +5 more
doaj +1 more source

