Results 91 to 100 of about 1,365,924 (292)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Physical activity and executive function in Chinese preschool children: the mediating role of sleep problems

open access: yesFrontiers in Psychology
ObjectiveThis study aimed to examine the relationship between physical activity and executive function in preschool children, with a particular focus on the mediating role of sleep problem.MethodsA total of 159 preschool children participated in this ...
Xiaolong Chen   +6 more
doaj   +1 more source

The association of specific executive functions and falls risk in people with mild cognitive impairment and early-stage dementia [PDF]

open access: yes, 2015
Background/Aims: Impairment in executive function is associated with a heightened risk for falls in people with mild cognitive impairment (MCI) and dementia.
Booth, Victoria   +7 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

The effect of cycling on cognitive function and well-being in older adults [PDF]

open access: yes, 2019
It has been demonstrated that, on their own, both exercise and stimulation from the environment can improve cognitive function and well-being in older adults.
Beale, Nick   +4 more
core   +3 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

Executive functions in insight versus non-insight problem solving: an individual differences approach [PDF]

open access: yes, 2009
Original article can be found at: http://www.informaworld.com/smpp/title~content=t713685607~db=all Copyright Informa / Taylor and FrancisThis study investigated the roles of the executive functions of inhibition and switching and of verbal and visuo ...
Fioratou, E., Gilhooly, K.
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Effects of Information and Communication Technology Use on the Executive Function of Older Adults without Dementia: A Longitudinal Fixed-Effect Analysis [PDF]

open access: yesAnnals of Geriatric Medicine and Research
Background Impaired executive function is common in older adults. This study examined the causal relationship between the use of information and communication technology (ICT) and executive function in older adults over time.
Hamin Lee   +5 more
doaj   +1 more source

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