Results 101 to 110 of about 1,348,181 (298)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Effects of Information and Communication Technology Use on the Executive Function of Older Adults without Dementia: A Longitudinal Fixed-Effect Analysis [PDF]

Annals of Geriatric Medicine and Research
Background Impaired executive function is common in older adults. This study examined the causal relationship between the use of information and communication technology (ICT) and executive function in older adults over time.
Hamin Lee, Sangmi Park, Seungho Han, Hyeon Dong Lee, Ickpyo Hong, Hae Yean Park   +5 more
doaj   +1 more source

Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI.

, 2004
Gradient echo T2*-weighted MRI has high sensitivity in detecting cerebral microbleeds, which appear as small dot-like hypointense lesions. Microbleeds are strongly associated with intracerebral haemorrhage, hypertension, lacunar stroke and ischaemic ...
Brown, Martin M, Cipolotti, Lisa, Coward, Lucy J, Frazer, Duncan W, Jäger, H Rolf, Losseff, Nick A, Watt, Hilary, Werring, David J   +7 more
core   +1 more source

Investigating the impact of nicotine on executive functions using a novel virtual reality assessment [PDF]

, 2012
Aims Nicotine is known to enhance aspects of cognitive functioning in abstinent smokers but the effects on specific areas of executive functions, and in non-smokers are inconclusive.
Al-Adawi, Alcaro, Ashendorf, Benowitz, Dani, Dawkins, Di Matteo, Durrazzo, Edginton, Einstein, Ellis, Evans, Foulds, Friedman, Grant, Heffernan, Heishman, Heishman, Hendricks, Hindmarch, Janhunen, Jansari, Kleykamp, Kumari, Le Houezec, Leventhal, Levin, Miyake, Montgomery, Montgomery, Montgomery, Mumenthaler, Myers, Neumann, Nooyens, Nyberg, Phillips, Pickworth, Poltavski, Powell, Rezvani, Rhodes, Russell, Rusted, Rusted, Rusted, Sabia, Schachter   +47 more
core   +4 more sources

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

The mediating role of nomophobia in the effect of executive function on problem-solving skills in gifted students

BMC Psychology
This study investigated the mediating role of nomophobia in the impact of executive function on problem-solving skills among a sample of Turkish gifted middle school students. This study employed a quantitative, non-experimental design using a relational
Muhammet Davut Gül, Zekai Ayık
doaj   +1 more source

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

Influence of perceived stress on executive function： the path of self-hate and negative affect in adolescents

Sichuan jingshen weisheng
BackgroundThe development of executive function in adolescents is influenced by many environmental factors. Previous studies have found that perceived stress is closely related to executive function， whereas its role in the mediation of executive ...
Zhu Jiaqi, Zhu Huiqun, Qi Meng, Gao Huanqin, Zhuang Yunyue, Chen Jingxu   +5 more
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source