Results 71 to 80 of about 3,237,470 (329)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hunger in America 2010 Executive Summary [PDF]

, 2010
Feeding America seeks not only to immediately alleviate hunger through distribution of food and grocery products to people in need, but also to address the problem of hunger in the long-term by increasing awareness among the public, connecting clients ...

core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Standards of Medical Care in Diabetes-2009 (American Diabetes Association): executive summary

Сахарный диабет, 2009
?Стандарты оказания медицинской помощи больным сахарным диабетом?, рекомендуемые Американской диабетической ассоциацией (АДА), являются одним из основных документов, регламентирующих деятельность медицинских специалистов по диагностике и лечению данного ...
Olga Konstantinovna Vikulova
doaj   +1 more source

The East Midlands in 2010: executive summary [PDF]

, 2010
The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. It presents a statistical portrait of the region covering demography, housing, economy & productivity, the labour market ...
Bickerton, CG
core  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management

Počki, 2018
No abstract Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and ...
No authors .
doaj   +1 more source

Executive Summary: Clinical Practice Guideline for Autosomal Dominant Polycystic Kidney Disease in China

Kidney Diseases, 2020
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, with a prevalence of 1/2,500–1/1,000, and it affects 1.25 million people in China.
Chang-Lin Mei, Cheng Xue, Sheng-Qiang Yu, Bing Dai, Jiang-Hua Chen, Ying Li, Li-Meng Chen, Zhang-Suo Liu, Yong-Gui Wu, Zhao Hu, Yan Zha, Hong Liu, Yong-Ze Zhuang, Chun Zhang, Xiang-Cheng Xiao, Yue Wang, Gui-Sen Li, Yi-Yi Ma, Lin Li   +18 more
doaj   +1 more source

NEXT-100 Technical Design Report (TDR). Executive Summary [PDF]

, 2012
In this Technical Design Report (TDR) we describe the NEXT-100 detector that will search for neutrinoless double beta decay (bbonu) in Xe-136 at the Laboratorio Subterraneo de Canfranc (LSC), in Spain.
Aparicio, J. L. Pérez, Borges, F. I. G. M., Carmona, J. M., Castel, J., Catalá, J. M., Cebrián, S., Cervera, A., Chan, D., Conde, C. A. N., Cárcel, S., da Luz, H. Natal, Dafni, T., Dias, T. H. V. T., Díaz, J., Egorov, M., Esteve, R., Evtoukhovitch, P., Fernandes, L. M. P., Ferrario, P., Ferreira, A. L., Ferrer-Ribas, E., Freitas, E. D. C., Gehman, V. M., Gil, A., Giomataris, I., Goldschmidt, A., González, K., González-Díaz, D., Gutiérrez, R. M., Gómez, H., Gómez-Cadenas, J. J., Hauptman, J., Herrera, D. C., Herrero, V., Iguaz, F. J., Irastorza, I. G., Kalinnikov, V., Kiang, D., Labarga, L., Liubarsky, I., Lopes, J. A. M., Lorca, D., Losada, M., Luzón, G., Martín-Albo, J., Martínez, A., Marí, A., Miller, T., Moiseenko, A., Monrabal, F., Monteiro, C. M. B., Monzó, J. M., Mora, F. J., Morata, J. A. Hernando, Moutinho, L. M., Navarro, G., Nebot, M., NEXT Collaboration, Nygren, D., Oliveira, C. A. B., Palma, R., Pérez, J., Renner, J., Ripoll, L., Rodríguez, A., Rodríguez, J., Santos, F. P., Santos, J. M. F. dos, Segui, L., Serra, L., Shuman, D., Sofka, C., Sorel, M., Toledo, J. F., Tomás, A., Torrent, J., Tsamalaidze, Z., Velicheva, E., Veloso, J. F. C. A., Vidal, J. Muñoz, Villar, J. A., Vázquez, D., Webb, R. C., Weber, T., White, J., Yahlali, N., Álvarez, V.   +86 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source