Results 51 to 60 of about 979,425 (244)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Effects of fractional inspired O2 on the O2 pathway during submaximal and maximal exercise in male endurance athletes

Physiological Reports
We utilized non‐invasive methods and novel computational approaches to examine the effects of acutely varying fractional inspired O2 (FIO2) on convective and diffusive steps of O2 transport and muscle tissue (de)oxygenation during incremental cycling to ...
Elias Lehtonen, Dominique D. Gagnon, Antti‐Pekka E. Rissanen, Tom Mikkola, Juha E. Peltonen   +4 more
doaj   +1 more source

Citrus Aurantium and caffeine complex versus placebo on biomarkers of metabolism: a double blind crossover design

Journal of the International Society of Sports Nutrition, 2019
Backgrouond The purpose of this study was to examine resting the metabolic response to the ingestion of a complex containing Citrus Aurantium + Caffeine (CA + C) and if its consumption influences metabolic recovery following a high-intensity anaerobic ...
Brian Kliszczewicz, Emily Bechke, Cassie Williamson, Zackery Green, Paul Bailey, John McLester, Cherilyn McLester   +6 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

The influence of citrus aurantium and caffeine complex versus placebo on the cardiac autonomic response: a double blind crossover design

Journal of the International Society of Sports Nutrition, 2018
Background The purpose of this study was to examine the resting cardiac autonomic nervous system’s response to the ingestion of a complex containing Citrus aurantium + Caffeine (CA + C) and its influence on recovery following a high-intensity anaerobic ...
Brian Kliszczewicz, Emily Bechke, Cassie Williamson, Paul Bailey, Wade Hoffstetter, John McLester, Cherilyn McLester   +6 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Prevalence and patterns of dietary supplement use in elite Spanish athletes

Journal of the International Society of Sports Nutrition, 2019
Background Dietary supplementation is a common strategy to achieve a specific health status or performance benefit. Several investigations have focused on the prevalence of dietary supplement use by athletes.
Gabriel Baltazar-Martins, Diego Brito de Souza, Millán Aguilar-Navarro, Jesús Muñoz-Guerra, María del Mar Plata, Juan Del Coso   +5 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The impact of low energy availability risk on pre-competition physiological function in Chinese female combat athletes

Journal of the International Society of Sports Nutrition
Background Low energy availability (LEA) can negatively impact athletes’ physiological function and performance. This study aims to examine the prevalence of LEA in Chinese female combat athletes and monitor changes in physiological function and ...
Yiheng Liang, Yuxuan Li, Yan Chen, Kun Meng, Fanyang Zhou, Yiran Pei, Yong Liu, Junqiang Qiu   +7 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source