Results 121 to 130 of about 1,276,748 (319)

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, EarlyView.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

High Intensity Resistive and Rowing Exercise Countermeasures Do Not Prevent Orthostatic Intolerance Following 70 Days of Bed Rest [PDF]

More than 60% of US astronauts participating in Mir and early International Space Station missions (greater than 5 months) were unable to complete a 10min 80 deg headup tilt test on landing day.
Laurie, Steven S., Lee, Stuart M. C., Platts, Steven H., Ploutz-Snyder, Lori L., Stenger, Michael B.   +4 more
core   +1 more source

Lewis Acid‐Activated Charge Trapping in Dielectric Polymers for Superior High‐Temperature Electrostatic Energy Storage

Advanced Science, EarlyView.
Lewis acid–base molecular engineering tailors the lowest unoccupied molecular orbital of polymers to form deep, homogeneous charge traps in commercial polyetherimide (PEI). These deep traps effectively inhibit the transport of injected charge carriers from electrodes, ultimately enabling ultrahigh energy density and thermal stability in dielectric ...
Lu Fan, Zongliang Xie, Xi Chen, Qingsong Zhang, Yalin Wang, He Li, Xi Pang, Tiffany Chen, Shiqi Lai, Zhiyuan Huang, Ashlin M. Deatherage, Hanjiang Gu, Meng Chen, Tao Han, Liana M. Klivansky, Steve W. Shelton, Peng Liu, Zongren Peng, Ting Xu, Jian Zhang, Yi Yin, Yi Liu   +21 more
wiley   +1 more source

Computational Content Analysis of Negative Tweets for Obesity, Diet, Diabetes, and Exercise

, 2017
Social media based digital epidemiology has the potential to support faster response and deeper understanding of public health related threats. This study proposes a new framework to analyze unstructured health related textual data via Twitter users ...
Karami, Amir, Shaw Jr., George
core   +1 more source

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

Advanced Science, EarlyView.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian, Yun Chen, Jingyi Zhou, Shilin Zhang, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

High Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Circulation, 2019
Inorganic phosphate (Pi) is used extensively as a preservative and a flavor enhancer in the Western diet. Physical inactivity, a common feature of Western societies, is associated with increased cardiovascular morbidity and mortality.
P. Peri-Okonny, Kedryn K. Baskin, G. Iwamoto, Jere H. Mitchell, Scott A. Smith, H. Kim, Luke I Szweda, R. Bassel-Duby, Teppei Fujikawa, Carlos M. Castro, J. Richardson, J. Shelton, C. Ayers, J. Berry, V. Malladi, M. Hu, O. Moe, Phillip E Scherer, W. Vongpatanasin   +18 more
semanticscholar   +1 more source

Can clinicians and scientists explain and prevent unexplained underperformance syndrome in elite athletes: an interdisciplinary perspective and 2016 update [PDF]

, 2015
The coach and interdisciplinary sports science and medicine team strive to continually progress the athlete's performance year on year. In structuring training programmes, coaches and scientists plan distinct periods of progressive overload coupled with ...
Collins, D., Lewis, N.A., Pedlar, C.R.,, Rogers, J.P   +3 more
core   +2 more sources

Immediate Reconstruction of Pancretaticogastrostomy Following Hepatopancreatoduodenectomy for Biliary Tact Cancer: A Single‐Center Review of 33 Consecutive Patients

Annals of Gastroenterological Surgery, EarlyView.
This study showed that the pancreaticogastrostomy technique in HPD of biliary tract cancer reduced the incidence of pancreatic fistula from 45% to 12%. In‐hospital mortality was also reduced from 27% to 3%. ABSTRACT Background and Purpose Although hepatopancreaticoduodenectomy (HPD) is effective for margin‐negative curative resection of biliary tract ...
Ryusei Matsuyama, Yasuhiro Yabusita, Tomoaki Takahashi, Yutaro Kikuchi, Kouta Sahara, Kentaro Miyake, Yu Sawada, Yuuki Homma, Takafumi Kumamoto, Itaru Endo   +9 more
wiley   +1 more source

Low Resting Diffusion Capacity, Dyspnea and Exercise Intolerance in COPD.

Journal of applied physiology, 2019
The mechanisms linking reduced diffusing capacity of the lung for carbon monoxide (DLCO) to dyspnea and exercise intolerance across the COPD continuum are poorly understood.
Amany F. Elbehairy, Conor D. J. O'Donnell, Asmaa Abd Elhameed, S. Vincent, K. Milne, M. James, K. Webb, J. Neder, D. O’Donnell   +8 more
semanticscholar   +1 more source

Time‐Dependent Recovery of Gastric Emptying After Gastrectomy: A 12‐Month Longitudinal Study Using a 13C‐Acetate Breath Test With a Semi‐Solid Meal

Annals of Gastroenterological Surgery, EarlyView.
This study examined time‐dependent changes in gastric emptying after gastrectomy for gastric cancer using a 13C‐acetate breath test with a semi‐solid meal in 95 patients, revealing that gastric emptying was initially delayed at 1 month but significantly accelerated by 12 months postoperatively.
Sachiko Kaida, Katsushi Takebayashi, Mika Kurihara, Reiko Otake, Haruki Mori, Hiromitsu Maehira, Toru Miyake, Shigeki Bamba, Masaji Tani   +8 more
wiley   +1 more source