Results 141 to 150 of about 1,276,748 (319)

Exercise Intolerance in Heart Failure: Central Role for the Pulmonary System.

Exercise and sport sciences reviews, 2019
We propose that abnormalities of the pulmonary system contribute significantly to the exertional dyspnea and exercise intolerance observed in patients with chronic heart failure.
S. Lalande, T. Cross, Manda L. Keller‐Ross, N. Morris, Bruce D. Johnson, B. Taylor   +5 more
semanticscholar   +1 more source

Echocardiography combined with cardiopulmonary exercise testing for the prediction of outcome in idiopathic pulmonary arterial hypertension [PDF]

, 2016
BACKGROUND: Right ventricular (RV) function is a major determinant of exercise intolerance and outcome in idiopathic pulmonary arterial hypertension (IPAH). The aim of the study was to evaluate the incremental prognostic value of echocardiography of the
Badagliacca, Roberto, Fedele, Francesco, Giannetta, E, Manzi, G, Naeije, R, Palange, Paolo, Papa, S, Pezzuto, Beatrice, Poscia, Roberto, Sciomer, S, Valli, G, Vizza, Carmine Dario   +11 more
core   +1 more source

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source

High Intensity Exercise Countermeasures does not Prevent Orthostatic Intolerance Following Prolonged Bed Rest [PDF]

Approximately 20% of Space Shuttle astronauts became presyncopal during operational stand and 80deg headup tilt tests, and the prevalence of orthostatic intolerance increases after longer missions.
Lee, Stuart M. C., Platts, Steven H., Ploutz-Snyder, Lori L., Stenger, Michael B.   +3 more
core   +1 more source

The HRAS Variant c.175G>A (p.Ala59Thr) Causes a Predominantly Ectodermal Phenotype Lacking Classic Costello Syndrome Features

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Costello syndrome (CS) is a rare dominant HRAS RASopathy characterized by curly hair, cardiac abnormalities, craniofacial anomalies, and developmental delay. HRAS codon 58, 59, and 60 variants are associated with milder phenotypes. We describe a three‐generation family with a previously unreported heterozygous HRAS variant c.175G>A (p.Ala59Thr)
Nikole Rautiainen, Eveliina Brandt, Kaisa Kettunen, Outi Elomaa, Sirpa Kivirikko, Leila Jeskanen, Katriina Lappalainen, Nelli Sjöblom, Juha Kere, Katariina Hannula‐Jouppi, Liisa Harjama   +10 more
wiley   +1 more source

Cardiopulmonary exercise testing in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Frontiers in Sports and Active Living
Cardiopulmonary exercise testing allows for a comprehensive assessment of the mechanism of exercise limitation in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
Alexis Coulis, Shir Levanon, Gurshaun Randhawa, Yevgeniy Brailovsky, Farhan Raza, Estefania Oliveros   +5 more
doaj   +1 more source

Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure

Journal of Cachexia, Sarcopenia and Muscle, 2018
Exercise intolerance is a common clinical feature and is linked to poor prognosis in patients with heart failure (HF). Skeletal muscle dysfunction, including impaired energy metabolism in the skeletal muscle, is suspected to play a central role in this ...
Masaya Tsuda, A. Fukushima, J. Matsumoto, S. Takada, Naoya Kakutani, Hideo Nambu, K. Yamanashi, T. Furihata, T. Yokota, K. Okita, S. Kinugawa, T. Anzai   +11 more
semanticscholar   +1 more source

De Novo Heterozygous ZFX Frameshift Variant in a Female With an X‐Linked Neurodevelopmental Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Germline ZFX variants are associated with an X‐linked neurodevelopmental disorder, with 14 males and 16 females reported to date. We describe a 20‐year‐old female with a heterozygous ZFX frameshift variant, p.(Met666Valfs*2), identified by genome sequencing, previously reported in an affected male.
Iftekhar A. Showpnil, Allison Daley, Emily R. Sites, Shayne M. Plourde, Jesse M. Hunter, Dennis W. Bartholomew, April N. Lehman, Daniel C. Koboldt, Rolf W. Stottmann   +8 more
wiley   +1 more source

Adaptive Approaches to Exercise Rehabilitation for Postural Tachycardia Syndrome and Related Autonomic Disorders

Archives of Rehabilitation Research and Clinical Translation
Exercise is a well-documented, nonpharmacologic treatment for individuals with autonomic dysfunction and associated orthostatic intolerance, such as postural tachycardia syndrome and related disorders.
Lauren Ziaks, PT, DPT, ATC, Kathryn Johnson, PT, DPT, Kelsi Schiltz, PT, DPT, Ryan Pelo, PT, DPT, PhD, Guillaume Lamotte, MD, MSc, Claudia Dal Molin, DO, RMSK, Tae Chung, MD, Melissa M. Cortez, DO   +7 more
doaj   +1 more source

Fatigue and exercise intolerance in mitochondrial diseases. Literature revision and experience of the Italian Network of mitochondrial diseases [PDF]

, 2012
Michelangelo Mancuso, C. Angelini, Enrico Bertini, Valério Carelli, Giacomo P. Comi, Carlo Minetti, Maurizio Moggio, Tiziana Mongini, Serenella Servidei, Paola Tonin, António Toscano, Graziella Uziel, Massimo Zeviani, Gabriele Siciliano   +13 more
openalex   +1 more source