Results 201 to 210 of about 53,568 (231)

Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
Macrophages stimulated by BCG significantly enhanced endothelial cell proliferation, migration, and tube formation. Mechanistically, this pro‐angiogenic activity was reliant on activating NF‐αB or other signaling pathways, which induced the upregulation of HIF‐1α and VEGFA.
Yuyang Hou, Yuxi Wang, Qiong Wu, Wenjing Du, Shanzhu Guo, Xinyu Chai, Yinan Wang, Huixin Liang, Hongyan Yuan, Jun Li, Dongmei Yan   +10 more
wiley   +1 more source

Medium- to long-term health condition of patients post-COVID-19, exercise intolerance and potential mechanisms: A narrative review and perspective. [PDF]

SAGE Open Med
Schwendinger F, Infanger D, Maurer DJ, Radtke T, Carrard J, Kröpfl JM, Emmenegger A, Hanssen H, Hauser C, Schwehr U, Hirsch HH, Ivanisevic J, Leuzinger K, Martinez AE, Maurer M, Sigrist T, Streese L, von Känel R, Hinrichs T, Schmidt-Trucksäss A.   +19 more
europepmc   +1 more source

Predicting Major Depression Among Diverse Online Gamers: The Role of Internet Addiction and Spirituality

Journal of Addictions &Offender Counseling, EarlyView.
ABSTRACT This study analyzed whether religious or spiritual affiliation and therapy enrollment protect against symptoms meeting Major Depressive Disorder criteria beyond demographic, Internet addiction, and described therapy enrollment. Findings illustrated one risk factor and one protective factor associated with experiencing symptoms that meet Major ...
Lindsay A. Lundeen, John R. McCall
wiley   +1 more source

Identification of a De Novo MAGEL2 Pathogenic Variant in Schaaf–Yang Syndrome and the Importance of Paternal Allele Confirmation

Journal of Clinical Laboratory Analysis, EarlyView.
This study reports a de novo MAGEL2 pathogenic variant in a patient with Schaaf–Yang syndrome, confirmed through methylation‐sensitive analysis. Combining genomic sequencing with methylation assays helps accurately determine the parental origin of MAGEL2 mutations.
Youn‐Ji Hong, Misun Yang, Hyeon Jeong Kwon, Jooyoung Cha, Ja‐Hyun Jang, Sung Eun Wang, Eun Sun Lee, Mi‐Ae Jang   +7 more
wiley   +1 more source

Predicting exercise intolerance in elderly individuals with heart failure using the 30-second chair stand test. [PDF]

Int J Cardiol Heart Vasc
Savino M, Savino L, Mone P, Schiano C, De Luca A, Santulli G.   +5 more
europepmc   +1 more source

Examining the Relationship Between Prospective and Inhibitory Intolerance of Uncertainty, Obsessive Compulsive Disorder Symptoms and Treatment Outcome

Journal of Clinical Psychology, EarlyView.
ABSTRACT Objectives Intolerance of uncertainty (IU) is a cognitive vulnerability factor that plays a role in obsessive compulsive disorder (OCD). Most research has looked at IU at an omnibus level. This paper aimed to investigate the two dimensions of IU, prospective and inhibitory IU, and their relation to overall OCD symptom severity, as well as the ...
Judith M. Laposa, Christina Puccinelli
wiley   +1 more source

Impatience for negative experiences

Journal of Consumer Psychology, EarlyView.
Abstract Conceptualizing impatience as an emotion, and patience as the regulation of that emotion, offers new insights and opportunities for the study of consumer behavior. While this framework has primarily been applied to impatience for positive events, many real‐life events of interest involve decisions about negative or mixed‐valence events.
David J. Hardisty
wiley   +1 more source

Targeting intolerance of uncertainty in young children diagnosed with autism: A randomized controlled trial of a parent‐mediated group intervention

JCPP Advances, EarlyView.
In this clinical trial, parents of young children between four and 7 years of age, diagnosed with autism and experiencing anxiety related to uncertainty, completed an 8 week group program. Post‐group, parents reported significant reductions in the impact of uncertainty‐related anxiety on their child and family, with effects also noted on parenting ...
Claudia S. Y. Ong, Jacqui Rodgers, Matthew N. Cooper, Zac Dempsey, Rebecca Eaton, Katia Haines, Rebecca Kuzminski, Iliana Magiati, Murray T. Maybery, Mirko Uljarević, John Wray, Andrew J. O. Whitehouse, Gail A. Alvares   +12 more
wiley   +1 more source

Recurrent Myalgia, Dark Urine, and Exercise Intolerance: Glycogen Storage Disease Type X Diagnosed Through Gene Sequencing Panel. [PDF]

Cureus
Furuta Y, Phillips JA.
europepmc   +1 more source

Why do attention‐deficit/hyperactive disorder and/or autism traits place adolescents at risk for depression? Protocol for a longitudinal comparison of the mediating role of emotion regulation deficits versus emotional burden

JCPP Advances, EarlyView.
This paper details the protocol for the My Emotions and Me Over Time (MEMO) study, a longitudinal study exploring why ADHD and/or autism traits place adolescents at greater risk for depression. This study will explore two potential mediating factors in pathways to depression: emotional regulation deficits; and emotional burden.
Edmund J. S. Sonuga‐Barke, Melanie Palmer, Kirsty Griffiths, Anna Wyatt, Andrea Danese, Susie Chandler, Daniel Stahl, Steve Lukito, Georgia Pavlopoulou, Emily Simonoff, on behalf ofthe RE‐STAR team   +10 more
wiley   +1 more source