Results 201 to 210 of about 1,276,748 (319)

Drug Repositioning of Pegbing® for Essential Thrombocythemia: Insights from PK/PD Modeling and Extrapolation

Clinical Pharmacology &Therapeutics, EarlyView.
Pegbing® (peginterferon alfa‐2b), a pegylated interferon‐alpha, is approved for the treatment of chronic hepatitis B (CHB) and C. One of its adverse effects is platelet (PLT) suppression. It is currently being repurposed for the treatment of essential thrombocythemia (ET), a rare myeloproliferative disorder characterized by abnormally elevated PLT ...
Weizhe Jian, Yalin Yin, Rong Chen, Junsheng Xue, Jianbo Gu, Zhengfang Du, Ruoyi He, Tianyan Zhou   +7 more
wiley   +1 more source

Echocardiographic Markers of Elevated Pulmonary Pressure and Left Ventricular Diastolic Dysfunction Are Associated With Exercise Intolerance in Adults and Adolescents With Homozygous Sickle Cell Anemia in the United States and United Kingdom [PDF]

, 2011
Vandana Sachdev, Gregory J. Kato, J. Simon R. Gibbs, Robyn J. Barst, Roberto F. Machado, Mehdi Nouraie, Kathryn L. Hassell, Jane A. Little, Dean E. Schraufnagel, Lakshmanan Krishnamurti, Enrico M. Novelli, Reda E. Girgis, Claudia R. Morris, Erika B. Rosenzweig, David B. Badesch, Sophie Lanzkron, Oswaldo Castro, James G. Taylor, Hwaida Hannoush, Jonathan C. Goldsmith, Mark T. Gladwin, Victor R. Gordeuk   +21 more
openalex   +1 more source

Effect of aerobic capacity on Lower Body Negative Pressure (LBNP) tolerance in females [PDF]

This investigation determined whether a relationship exists in females between: (1) aerobic capacity and Lower Body Negative Pressure (LBNP); and (2) aerobic capacity and change in LBNP tolerance induced by bed rest. Nine females, age 27-47 (34.6 plus or
Fortney, Suzanne M., Moore, Alan D., Jr., Siconolfi, Steven F.   +2 more
core   +1 more source

School spaces of dissensus: Protecting sexualities education in anti‐gender, anti‐Muslim and de‐democratising times

The Curriculum Journal, EarlyView.
Abstract This paper examines the intensified conflict over sexualities education curricula brought about by anti‐(trans)gender and anti‐Muslim policy and political discourse transnationally. Backlash against inclusive sexualities education has taken shape across several policy territories, driven in part by de‐democratising right‐wing populist ...
James Sutton, Deborah Youdell, Karl Kitching   +2 more
wiley   +1 more source

Exploring university student perspectives of a challenge‐based curriculum

The Curriculum Journal, EarlyView.
Abstract The world faces multiple global and local challenges, with some describing one challenge, climate breakdown, as an existential threat. Publications in this journal have highlighted the importance of curricula that help students better understand and address these challenges.
Miles Thompson, Alpesh Maisuria, Shona McCartney, Rhianna Hamilton   +3 more
wiley   +1 more source

PHKA1-associated phosphorylase kinase deficiency: a monogenic disorder of exercise intolerance and myalgia. [PDF]

NPJ Genom Med
Koch RL, Fares AH, Cocanougher BT, Lim J, Haijer-Schreuder AB, Derks TGJ, Grünert SC, Sharma R, Jones KA, Kishnani PS.   +9 more
europepmc   +1 more source

Development of equipment that promotes exercise training for children with orthostatic intolerance [PDF]

Yuko Ishizaki, Yoshitoki Yanagimoto, Akihiko Yoshida, Kiyoshi Hayakawa, Kazunari Kaneko   +4 more
openalex   +1 more source

Metformin in the Horse: Pharmacokinetics and Detection Times Using Monte Carlo Simulations

Drug Testing and Analysis, EarlyView.
In recent years, the detection of metformin in blood and urine samples collected from racehorses has raised concern among regulators. This study describes blood and urine concentrations and the pharmacokinetics of metformin following IV and oral administration to horses. Data presented here can be used to establish screening limits and withdrawal times
Megan E. Jacobs, Jeff Blea, Michael Hardy, Daniel S. McKemie, Megan Traynham, Heather K. Knych   +5 more
wiley   +1 more source

Parenting Stress in Adolescent Anorexia Nervosa: Differential Stress in Mothers and Fathers During Inpatient Treatment

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder that impacts both the adolescents themselves and their parents. Parenting stress is associated with impaired mental health of parents and poorer treatment outcomes for their children.
V. Stonawski, J. Kutzner, S. Büscher, A. Hoyer, O. Kratz, S. Horndasch   +5 more
wiley   +1 more source

Body Image Surveys to Address Social Appearance Anxiety in Women at Risk of Eating Psychopathology: An Acceptability, Feasibility and Preliminary Efficacy Study, Using a Wait‐List Randomized Controlled Design

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The study investigated the feasibility, acceptability and preliminary efficacy of a body image survey intervention for women at risk of eating psychopathology. Method A randomized wait‐list control design was used. The preregistered study (https://doi.org/10.17605/OSF.IO/ZQPEU) had ethical clearance and met recruitment targets ...
Emma Giles, Glenn Waller
wiley   +1 more source