Results 21 to 30 of about 53,568 (231)

Fatigue and Exercise Intolerance as Initial Manifestations of a Nonsyndromic Mitochondrial Disorder Due to the Variant m.3243A>G

Case Reports in Neurological Medicine, 2022
Objectives. Fatigue and exercise intolerance have been only rarely reported as initial- and sole-onset manifestations of a mitochondrial disorder (MID).
Josef Finsterer, Sinda Zarrouk
doaj   +1 more source

Recurrent rhabdomyolysis and exercise intolerance: A new phenotype of late-onset thymidine kinase 2 deficiency

Molecular Genetics and Metabolism Reports, 2021
A 29-year-old man developed, since the age of 18, exercise intolerance and exercise-induced rhabdomyolysis, with myoglobinuria. Muscle biopsy showed ragged-red fibers. Multiple mitochondrial DNA deletions were detected. The previously reported pathogenic
Carlos Pablo de Fuenmayor-Fernández de la Hoz, Germán Morís, Cecilia Jiménez-Mallebrera, Carmen Badosa, Aurelio Hernández-Laín, Alberto Blázquez Encinar, Miguel Ángel Martín, Cristina Domínguez-González   +7 more
doaj   +1 more source

Combined use of stress echocardiography and cardiopulmonary exercise testing to assess exercise intolerance in patients treated for acute myocardial infarction.

PLoS ONE, 2021
Exercise intolerance after acute myocardial infarction (AMI) is a predictor of worse prognosis, but its causes are complex and poorly studied. This study assessed the determinants of exercise intolerance using combined stress echocardiography and ...
Krzysztof Smarz, Tomasz Jaxa-Chamiec, Beata Zaborska, Maciej Tysarowski, Andrzej Budaj   +4 more
doaj   +2 more sources

Consequences of group III/IV afferent feedback and respiratory muscle work on exercise tolerance in heart failure with reduced ejection fraction

Experimental Physiology, 2023
Exercise intolerance and exertional dyspnoea are the cardinal symptoms of heart failure with reduced ejection fraction (HFrEF). In HFrEF, abnormal autonomic and cardiopulmonary responses arising from locomotor muscle group III/IV afferent feedback is one
Joshua R. Smith, Jonathon W. Senefeld, Kathryn F. Larson, Michael J. Joyner   +3 more
doaj   +1 more source

Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF

Frontiers in Cardiovascular Medicine, 2023
Heart failure (HF) is a chronic and progressive syndrome affecting worldwide billions of patients. Exercise intolerance and early fatigue are hallmarks of HF patients either with a reduced (HFrEF) or a preserved (HFpEF) ejection fraction.
Norman Mangner, Ephraim B. Winzer, Axel Linke, Volker Adams, Volker Adams   +4 more
doaj   +1 more source

Pure exercise intolerance and ophthalmoplegia associated with the m.12,294G > A mutation in the MT-TL2 gene: a case report

BMC Musculoskeletal Disorders, 2017
Background Pure exercise intolerance associated with exclusive affection of skeletal muscle is a very rare phenotype of patients with mitochondrial myopathy.
Patrick Soldath, Karen Lindhardt Madsen, Astrid Emilie Buch, Morten Duno, Flemming Wibrand, John Vissing   +5 more
doaj   +1 more source

Skeletal Muscle Fatigability in Heart Failure

Frontiers in Physiology, 2019
Evidence suggests that heart failure (HF) patients experience skeletal muscle fatigability in the lower extremity during single-limb tasks. The contribution of skeletal muscle fatigability to symptoms of exercise intolerance (perceived fatigue and ...
Manda L. Keller-Ross, Mia Larson, Bruce D Johnson   +2 more
doaj   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Assessing Exercise Limitation Using Cardiopulmonary Exercise Testing

Pulmonary Medicine, 2012
The cardiopulmonary exercise test (CPET) is an important physiological investigation that can aid clinicians in their evaluation of exercise intolerance and dyspnea. Maximal oxygen consumption (V˙O2max) is the gold-standard measure of aerobic fitness and
Michael K. Stickland, Scott J. Butcher, Darcy D. Marciniuk, Mohit Bhutani   +3 more
doaj   +1 more source

Impaired Right Ventricular Mechanics at Rest and During Exercise Are Associated With Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Impaired right ventricular (RV) function indicates RV involvement in patients with hypertrophic cardiomyopathy (HCM). We aimed to assess RV function at rest and during exercise in HCM patients and to examine the association between impaired RV
Xiao‐Peng Wu, Yi‐Dan Li, Yi‐Dan Wang, Miao Zhang, Wei‐Wei Zhu, Qi‐Zhe Cai, Wei Jiang, Lan‐Lan Sun, Xue‐Yan Ding, Xiao‐Guang Ye, Yun‐Yun Qin, Xiu‐Zhang Lu   +11 more
doaj   +1 more source