Results 61 to 70 of about 1,276,748 (319)

Clinical Severity Score System in Dogs with Degenerative Mitral Valve Disease [PDF]

, 2015
BACKGROUND: Several risk factors already have been determined for dogs with degenerative mitral valve disease (DMVD). Risk factors often have been considered in isolation and have not always taken into account additional information provided by the ...
Atkins, Borgarelli, Borgarelli, Borgarelli, Boswood, Boswood, Chetboul, DeFrancesco, Doxey, Ferasin, Fujii, Gill, Haggstrom, Haggstrom, Haggstrom, Haggstrom, Haggstrom, Haggstrom, Hezzell, Kittleson, Ljungvall, Lord, López-Alvarez, Miller, Moonarmart, Ohad, Olsen, Pedersen, Pedersen, Reynolds, Schober, Tarnow   +31 more
core   +2 more sources

Assessing Exercise Limitation Using Cardiopulmonary Exercise Testing

Pulmonary Medicine, 2012
The cardiopulmonary exercise test (CPET) is an important physiological investigation that can aid clinicians in their evaluation of exercise intolerance and dyspnea. Maximal oxygen consumption (V˙O2max) is the gold-standard measure of aerobic fitness and
Michael K. Stickland, Scott J. Butcher, Darcy D. Marciniuk, Mohit Bhutani   +3 more
doaj   +1 more source

Exercise intolerance and rapid skeletal muscle energetic decline in human age-associated frailty

JCI Insight, 2020
BACKGROUND Physical frailty in older individuals is characterized by subjective symptoms of fatigue and exercise intolerance (EI). Objective abnormalities in skeletal muscle (SM) mitochondrial high-energy phosphate (HEP) metabolism contribute to EI in ...
S. Lewsey, K. Weiss, K. Weiss, M. Schär, Yi Zhang, P. Bottomley, T. Samuel, Q. Xue, Angela M Steinberg, J. Walston, G. Gerstenblith, R. Weiss   +11 more
semanticscholar   +1 more source

Skeletal muscle power and fatigue at the tolerable limit of ramp-incremental exercise in COPD [PDF]

, 2016
Muscle fatigue (a reduced power for a given activation) is common following exercise in COPD. Whether muscle fatigue, and reduced maximal voluntary locomotor power, are sufficient to limit whole-body exercise in COPD is unknown.
Ana Claudia Coelho, Andrew Cheng, Daniel T. Cannon, Harry B. Rossiter, Janos Porszasz, Jones NL, Richard Casaburi, Robert Cao   +7 more
core   +1 more source

Exercise and hypertrophic cardiomyopathy: Two incompatible entities? [PDF]

, 2020
A greater understanding of the pathogenic mechanisms underpinning hypertrophic cardiomyopathy (HCM) has translated to improved medical care and better survival of affected individuals.
Basu, J, Malhotra, A, Papadakis, M
core   +1 more source

Impaired Right Ventricular Mechanics at Rest and During Exercise Are Associated With Exercise Capacity in Patients With Hypertrophic Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Impaired right ventricular (RV) function indicates RV involvement in patients with hypertrophic cardiomyopathy (HCM). We aimed to assess RV function at rest and during exercise in HCM patients and to examine the association between impaired RV
Xiao‐Peng Wu, Yi‐Dan Li, Yi‐Dan Wang, Miao Zhang, Wei‐Wei Zhu, Qi‐Zhe Cai, Wei Jiang, Lan‐Lan Sun, Xue‐Yan Ding, Xiao‐Guang Ye, Yun‐Yun Qin, Xiu‐Zhang Lu   +11 more
doaj   +1 more source

Effect of selective heart rate slowing in heart failure with preserved ejection fraction [PDF]

, 2015
Background Heart failure with preserved ejection fraction (HFpEF) is associated with significant morbidity and mortality but is currently refractory to therapy.
Ashrafian, Houman, Dawson, Dana K., Dwight, Jeremy S., Francis, Jane M., Frenneaux, Michael, Mahmod, Masliza, Neubauer, Stefan, Pal, Nikhil, Rudd, Amelia, Singh, Satnam, Sivaswamy, Nadiya, Watkins, Hugh, Yavari, Arash   +12 more
core   +2 more sources

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

The association between normal lung function and peak oxygen uptake in patients with exercise intolerance and coronary artery disease.

PLoS ONE, 2020
In coronary artery disease (CAD), exercise intolerance with reduced oxygen uptake at peak exercise (VO2peak) is assumed to primarily reflect cardiovascular limitation.
Øystein Rasch-Halvorsen, Erlend Hassel, Ben M Brumpton, Haldor Jenssen, Martijn A Spruit, Arnulf Langhammer, Sigurd Steinshamn   +6 more
doaj   +1 more source

Mechanisms to dyspnoea and dynamic hyperinflation related exercise intolerance in COPD [PDF]

, 2015
Expiratory flow limitation can develop in parallel with the progression of COPD, and as a consequence, dynamic hyperinflation and lung mechanical abnormalities can develop.
Varga, Janos
core   +1 more source