Results 71 to 80 of about 1,276,748 (319)

Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure

Journal of Physiology, 2020
Heart failure patients with reduced ejection fraction (HFrEF) exhibit severe limitations in exercise capacity ( V̇O2 peak). One of the primary peripheral mechanisms suggested to underlie exercise intolerance in HFrEF is excessive locomotor muscle group ...
Joshua R Smith, M. Joyner, T. Curry, B. Borlaug, Manda L. Keller‐Ross, E. V. Van Iterson, T. Olson   +6 more
semanticscholar   +1 more source

Lack of beta(2)-adrenoceptors aggravates heart failure-induced skeletal muscle myopathy in mice [PDF]

, 2014
Skeletal myopathy is a hallmark of heart failure (HF) and has been associated with a poor prognosis. HF and other chronic degenerative diseases share a common feature of a stressed system: sympathetic hyperactivity.
Bacurau, Aline V. N., Bechara, Luiz R. G., Brum, Patricia C., Bueno, Carlos R., Casarini, Dulce E., Dourado, Paulo M. M., Mattos, Katt C., Negrao, Carlos E., Voltarelli, Vanessa A.   +8 more
core   +1 more source

The inhibitory SAPS3–AMPK interaction detected in HEK293 cells is not detectable in muscle or liver from humans or mice

FEBS Letters, EarlyView.
This study challenges the idea that Sit4‐associated protein subunit 3 (SAPS3) inhibits the energy‐sensing enzyme AMP‐activated protein kinase (AMPK) in muscle and liver tissue. Although SAPS3 interacts with AMPK in cultured cells, we found no such interaction in human or mouse tissues subjected to fasting, exercise, or a high‐fat diet.
Jesper B. Birk, Maria A. Møller, Jørgen F.P. Wojtaszewski, Rasmus Kjøbsted   +3 more
wiley   +1 more source

How do Physical Activity and Exercise affect Fabry Disease? Exploring a New Opportunity

Kidney & Blood Pressure Research
Background: Fabry disease (FD) is a multisystem, monogenic, X-linked storage disorder caused by mutations in the GLA gene, resulting in reduced alfa-galactosidase A enzyme activity.
Federica Baciga, Giacomo Marchi, Federica Caccia, Claudia Momentè, Pasquale Esposito, Filippo Aucella, Nicola Vitturi, Laura Pederzoli, Meilad Shakkour, Antonio Granata, Maria Teresa Zicarelli, Domenico Girelli, Michele Andreucci, Gianni Carraro, Yuri Battaglia   +14 more
doaj   +1 more source

Persistent exercise intolerance after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension

European Respiratory Journal, 2020
Aim Haemodynamic normalisation is the ultimate goal of pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH). However, whether normalisation of haemodynamics translates into normalisation of exercise capacity is unknown.
D. Ruigrok, L. Meijboom, E. Nossent, A. Boonstra, N. Braams, J. van Wezenbeek, F. D. de Man, J. Marcus, A. Vonk Noordegraaf, P. Symersky, H. Bogaard   +10 more
semanticscholar   +1 more source

Functional Assessment of Heart Failure Patients

, 2015
Heart failure (HF) is the condition characterized by the inability of the heart to pump sufficient blood to meet the demands of the body. It has been well established that both the prevalence and incidence of HF is increasing.1 There are 2 primary types ...
Imboden, Mary T., Kaminsky, Leonard A.
core   +1 more source

Long-term outcome after tricuspid valvectomy in a neonate with Candida endocarditis : a case report [PDF]

, 2019
Tricuspid valvectomy is a rare surgical intervention, and knowledge regarding long-term outcome in children is lacking. We report a favourable outcome 11 years after tricuspid valvectomy in early infancy without subsequent surgery or other cardiac ...
Bogers, Ad JJC, Helbing, Willem A, Vanhie, Ellen   +2 more
core   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Dietary fat intake as a risk factor for the development of diabetes. Multinational, multicenter study of the Mediterranean Group for the Study of Diabetes (MGDS) [PDF]

, 2003
In the context of the Multinational MGSD Nutrition Study, three groups of subjects were studied: 204 subjects with recently diagnosed diabetes(RDM),42subjectswithundiagnoseddiabetes(UDM)(AmericanDiabetesAssociation criteria—fasting plasma glucose [FPG ...
ANGELICO, Francesco, ASSAADKHALIL S., BARBATO A., DEL BEN, Maria, DIMITRIJEVICSRECKOVIC V., DJORDJEVIC P., GALLOTTI C., KARAMANOS B., KATSILAMBROS N., MIGDALIS I., MRABET M, PETKOVA M., ROUSSI D., TENCONI M. T., THANOPOULOU A.   +14 more
core   +1 more source

Long COVID in People With Multiple Sclerosis and Related Disorders: A Multicenter Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Managing long COVID in people with multiple sclerosis and related disorders (pwMSRD) is complex due to overlapping symptoms. To address evidence gaps, we evaluated long COVID susceptibility in pwMSRD versus controls and its associations with multi‐domain function and disability.
Chen Hu, Jiyeon Son, Lindsay McAlpine, Elizabeth L. S. Walker, Megan Dahl, Emily Song, Sugeidy Ferreira Brito, Katelyn Kavak, Kaho Onomichi, Amit Bar‐Or, Christopher Perrone, Claire S. Riley, Bianca Weinstock‐Guttman, Philip L. De Jager, Erin E. Longbrake, Zongqi Xia   +15 more
wiley   +1 more source