Results 31 to 40 of about 149,381 (254)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Exercise and Recovery Responses to the Intensity of Walking during Pregnancy and Postpartum [PDF]

open access: yes운동과학, 2017
PURPOSE To examine the influence of the walking exercise intensity during pregnancy and postpartum on physiological and perceived exertion responses. METHODS Nine participants walked on a treadmill at 3, 5, and 6 km/h for 10 minutes followed by resting ...
Somi Yun   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Determination of moderate walking intensity using step rate and VO2 reserve in healthy men

open access: yesBMC Public Health
Objective This study investigated step rates (SR) during overground walking to estimate the relative aerobic capacity that corresponds to a moderate intensity.
Woo Ram Bae   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Training-specific effects on metabolic-inflammatory mediators: GLP-1 and Dectin-1 changes following resistance, continuous, or interval exercise in overweight women [PDF]

open access: yesJournal of Exercise & Organ Cross Talk
The purpose of this study was to examine the effects of eight weeks of resistance, continuous endurance, and interval endurance training on Dectin-1 and Glucagon-Like Peptide-1 levels in overweight women. A total of 40 women, aged between 25 and 35 years
Leila Nouri Ain   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Human Microbiome Alterations in Antarctic Isolated, Confined, and Extreme (ICE) Environments: A Systematic Review and Meta-Regression

open access: yesInternational Journal of Microbiology
Antarctica is one of the most extreme and isolated environments on Earth, serving as a natural laboratory for studying human physiological and microbial adaptation under stress.
Mateus S. Rumão   +11 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Physical activity counteracts tumor cell growth in colon carcinoma C26-injected muscles: an interim report

open access: yesEuropean Journal of Translational Myology, 2016
Skeletal muscle tissue is a rare site of tumor metastasis but is the main target of the degenerative processes occurring in cancer-associated cachexia syndrome.
Charlotte Hiroux   +5 more
doaj   +1 more source

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