Results 41 to 50 of about 149,381 (254)

Exercise physiology in COPD.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 2003
Multiple mechanisms contribute to exercise limitation in chronic obstructive pulmonary disease (COPD). The ability to increase ventilation during exercise is reduced; the more advanced the disease, the more impaired the exercise tolerance is. However, factors other than ventilatory limitation play an important role in reducing the exercise capacity in ...
R. Antonucci, E. Berton, A. Huertas, P. Laveneziana, PALANGE, Paolo   +4 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Combined Exercise and Ursolic Acid Improve Hippocampal Neuronal Markers and Exploratory-Locomotor Behavior in Aged Diabetic Rats

Journal of Aging Research
Conclusion: The study demonstrated that diabetes leads to a marked elevation in NFL, Ng, and VILIP-1 protein levels, while a combined intervention of exercise and UA mitigated neurodegenerative changes and improved exploratory-locomotor outcomes.
Safoura Alizade, Abbas Ali Gaeini, Mohammad Faramarzi   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Effect of a 4 Week Isometric Handgrip Training on Changes of Peripheral Resistance and Blood Pressure in Women Suffering from Hypertension

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2017
Introduction: According to many studies, hypertension is considered as the second leading risk factor for coronary artery disease (CAD) and cardiac infarction after smoking The purpose of the present study was to investigate the effect of four weeks of ...
N Haji Tehrani, F Daryanoosh, MA Babaee Beygi, AR Rasekhi, M Koushki Jahromi, M Mohazzab   +5 more
doaj  

Investigating academic performance and perceptions of human physiology and exercise physiology courses among undergraduate students of physical education at a Brazilian public university

BMC Medical Education
Purpose To compare the academic performance of undergraduate students in physical education who studied exercise physiology before and after studying human physiology and investigate students’ perceptions of human physiology and exercise physiology ...
Mila Alves Matos Rodrigues, Rizia Rocha Silva, Douglas Assis Teles Santos, João Victor Rosa de Freitas, Paulo Gentil, Carlos Alexandre Vieira, Ana Cristina Silva Rebelo, Marília Santos Andrade, Mário Hebling Campos, Gustavo de Conti Teixeira Costa, Beat Knechtle, Rodrigo Luiz Vancini, Claudio Andre Barbosa de Lira   +12 more
doaj   +1 more source

Describing dietary patterns of high-intensity functional training athletes: a cross-sectional study

Journal of the International Society of Sports Nutrition
Background High-Intensity Functional Training (HIFT; e.g. CrossFitⓇ, F45Ⓡ, HyroxⓇ) is rapidly increasing in global participation. HIFT is a strenuous form of training that requires adequate dietary practices to optimize recovery and performance. However,
Linh Nguyen, Kworweinski Lafontant, Claudia Gonzalez, Susan Kampiyil, Michelle Da Silva Barbera, Jack Livingston, Sofea Smith, Jeffrey R. Stout, David H. Fukuda   +8 more
doaj   +1 more source