Results 61 to 70 of about 732,546 (337)

Encoding Cardiopulmonary Exercise Testing Time Series as Images for Classification using Convolutional Neural Network [PDF]

open access: yesarXiv, 2022
Exercise testing has been available for more than a half-century and is a remarkably versatile tool for diagnostic and prognostic information of patients for a range of diseases, especially cardiovascular and pulmonary. With rapid advancements in technology, wearables, and learning algorithm in the last decade, its scope has evolved.
arxiv  

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

Less Power for More Learning: Restricting OCaml Features for Effective Teaching [PDF]

open access: yesarXiv, 2023
We present a framework for sandboxing and restricting features of the OCaml programming language to effectively automate the grading of programming exercises, scaling to hundreds of submissions. We describe how to disable language and library features that should not be used to solve a given exercise.
arxiv  

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Evaluation of Systems Programming Exercises through Tailored Static Analysis [PDF]

open access: yes
In large programming classes, it takes a significant effort from teachers to evaluate exercises and provide detailed feedback. In systems programming, test cases are not sufficient to assess exercises, since concurrency and resource management bugs are difficult to reproduce. This paper presents an experience report on static analysis for the automatic
arxiv   +1 more source

A Wearable Rehabilitation System to Assist Partially Hand Paralyzed Patients in Repetitive Exercises [PDF]

open access: yesJournal of Physics: Conference Series. Vol. 1279. No. 1. IOP Publishing, 2019
The main purpose of the paper is development, implementation, and testing of a low-cost portable system to assist partially paralyzed patients in their hand rehabilitation after strokes or some injures. Rehabilitation includes time consuming and repetitive exercises which are costly and demotivating as well as the requirements of clinic attending and ...
arxiv   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Evaluation of blood pressure responses to treadmill exercise test in normotensive children of hypertensive parents

open access: yesThe Turkish Journal of Pediatrics, 2020
Background. Hypertension is a progressive disease with a prehypertensive phase. The most important feature of this period is the abnormal cardiovascular reactivity to various stressors.
Gökmen Özdemir   +2 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

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