Results 31 to 40 of about 2,889 (160)

Dermatologic Toxicities Associated With Novel Pan‐RAS/RAF Inhibitors

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background The mitogen‐activated protein kinase (MAPK) pathway plays a key role in cell‐cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan‐RAS (RMC‐6236) and pan‐RAF (LXH254/naporafenib) inhibitors are emerging.
Lin J. He, Shaymaa Hegazy, Phyu P. Aung, Priyadharsini Nagarajan, Fiorinda Muhaj, Adrienne N. Choksi, Ana M. Ciurea, Kelly C. Nelson, Doina Ivan, Carlos A. Torres‐ Cabala, Victor G. Prieto, Jonathan L. Curry   +11 more
wiley   +1 more source

COMPARATIVE CORRELATION OF EXFOLIATIVE CYTOLOGY AND INCISIONAL BIOPSY HISTOPATHOLOGY DIAGNOSING ORAL LEUKOPLAKIA’S IN SINDH HYDERABAD, PAKISTAN

Journal of University Medical & Dental College, 2020
BACKGROUND & OBJECTIVES: The malignant neoplasms especially oral leukoplakia’s are recognized as a complex tumor with unique morphology. Current study aims to evaluate 182 clinically confirmed cases of oral leukoplakia with complete demographics.
Waqas Iqbal, Arhama Surwaich , Surwaich Ali Channa , Abid Hussain Chang   +3 more
doaj  

Micronucleus Frequency Test in Epithelial Cells Desquamated From the Oral Mucosa of Patients With Fanconi Anemia

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Fanconi anemia (FA) is a rare genetic disorder predisposing patients to oral squamous cell carcinoma (OSCC). Hematopoietic stem cell transplantation (HSCT) corrects bone marrow failure but may increase the risk of malignancies. Exfoliative cytology and the micronucleus (MN) test provide noninvasive assessment of genomic instability.
Bárbara Soldatelli Ballardin, Pâmela Olivia de Moura, Pedro Leonardo Czmola de Lima, Juliana Lucena Schussel, Cassius Carvalho Torres‐Pereira   +4 more
wiley   +1 more source

Increased Genetic Instability in Exfoliated Oral Cells in Patients With Epidermolysis Bullosa

Oral Diseases, EarlyView.
ABSTRACT Objective To analyze the nuclear abnormalities of cytotoxicity—karyorrhexis (KR), karyolysis (KL), and pyknosis (PN)—and genotoxicity—micronucleus (MN) in exfoliated cells from different sites of the oral mucosa in patients with Epidermolysis Bullosa (EB) and a control group.
Ana Carolina Sias Franco Franzosi, Rebeca Ferreira Badaró, Lucas Fernandes Leal, Rosalie Matuk Fuentes Torrelio, Willian Grassi Bautz, Leticia Nogueira da Gama‐de‐Souza   +5 more
wiley   +1 more source

Standardising Assessment of Superficial Pyoderma in Dogs: Proposal of a Severity Score

Veterinary Dermatology, EarlyView.
Background: Superficial pyoderma is common in dogs with atopic dermatitis, yet no validated and widely accepted severity scoring system exists. Hypothesis/Objectives: To develop a predictor for superficial pyoderma severity based on reliable objective lesion quantification combined with a clinician‐assigned numerical severity rating.
Mickaël Pinto, David Grass, Ina Herrmann   +2 more
wiley   +1 more source

Cytomorphometric and cytomorphologic analysis of oral mucosa in children with sickle cell anemia

Journal of Cytology, 2013
Background: Sickle cell anemia (SCA) is an autosomal recessive genetic disorder, characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs, consequence of vaso occlusive phenomenon and vasculopathy ...
Juliana Umetsu Paraizo, Itauana Aliete Vettorello Rech, Luciana Reis Azevedo-Alanis, Mara Albonei Dudeque Pianovski, Antonio Adilson Soares De Lima, Maria Ângela Naval Machado   +5 more
doaj   +1 more source

Comparative Cytomorphometric Study of Exfoliated Squamous Buccal Cells among Patients with Iron Deficiency Anaemia and Healthy Individuals in Saurashtra, Gujarat, India

International Journal of Anatomy Radiology and Surgery, 2022
Introduction: Cytology is a fast, simple, non invasive, and bloodless procedure. Cytology can be useful in cases where biopsy is contraindicated or not needed, such as in systemically compromised patients, inaccessible areas, recurrent malignancies and ...
Ritika M Patel, Ridhdhish K Patel
doaj   +1 more source

Clinical Efficacy of Probiotic‐Based Ear Drops Containing Lactobacilli in Canine Erythroceruminous Otitis Externa: An Open Label, Multicentre Study

Veterinary Dermatology, EarlyView.
Background: Otitis externa (OE) represents a common clinical problem in dogs. Allergic dogs exhibit reduced diversity of the otic microbiota, and inflammation‐induced changes in the ear canal microenvironment result in a further decline in microbial biodiversity.
Isaac Carrasco, Josep Homedes, Antonio Arcas, Shea Beasley, Marta Salichs   +4 more
wiley   +1 more source

Brush Cytology with Immunocytochemical Evaluation of VEGF Expression versus Biopsy in Clinically Precancerous Laryngeal Lesions: Can We Diagnose Laryngeal Cancer Only with Brush Cytology?

Analytical Cellular Pathology, 2015
Introduction. Laryngeal squamous cell carcinoma (LSCC) is the most common SCC of the head and neck. The high incidence of this malignancy and the low survival rate necessitate the development of novel diagnostic approaches.
Angelos Chatziavramidis, Zinovia Tsinaslanidou, Rozalia Valeri, Iordanis Konstantinidis, Jannis Constantinidis   +4 more
doaj   +1 more source

An inter-correlative study on clinico-pathological profile and different predisposing factors of oral leukoplakia among the ethnics of Darjeeling, India

Journal of Orofacial Sciences, 2017
Context: Idiopathic leukoplakia is the most common potentially malignant disorder of oral cavity. Owing to the year-wide cold environment in Darjeeling, here the indigenous ethnic people practice a distinct addiction pattern that strongly predisposes ...
Krishnendu Mondal, Rupali Mandal, Badal C Sarkar, Vaswati Das   +3 more
doaj   +1 more source