Results 41 to 50 of about 142,488 (317)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
MATEC Web of Conferences, 2017 Exhaust emissions especially from light duty gasoline engine are a major contributor to air pollution due to the large number of vehicles on the road. The purpose of this study is to experimentally analyse the exhaust pollutant emissions of a four-stroke
Yusri I.M. +5 more
doaj +1 more source
Open Engineering, 2021 In order to better reflect the actual ecological performance of vehicles in traffic conditions, both the emission standards and the applied emission tests are being developed, for example by considering exhaust emissions for a cold engine start.
Pielecha Jacek +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Energies, 2022 The global automotive industry is undergoing a significant transition as battery electric vehicles enter the market and diesel sales decline. It is widely recognized that internal combustion engines (ICE) will be needed for transport for years to come ...
Praveen Kumar +4 more
doaj +1 more source
High-speed Civil Transport Aircraft Emissions [PDF]
, 1992 Estimates are given for the emissions from a proposed high speed civil transport (HSCT). This advanced technology supersonic aircraft would fly in the lower stratosphere at a speed of roughly Mach 1.6 to 3.2 (470 to 950 m/sec or 920 to 1850 knots ...
Albers, Martin +9 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Switzerland's PM10 and PM2.5 environmental increments show the importance of non-exhaust emissions
Atmospheric Environment: X, 2021 Atmospheric particulate matter (PM) is a priority pollutant for urban air pollution management because of its negative effects on human health and visibility.
Stuart K. Grange +8 more
doaj +1 more source
Data reduction and evaluation procedures [PDF]
, 1976 The computational procedures that are involved in exhaust emissions data reduction and the use of these computational procedures for determining the quality of the data that is obtained from exhaust measurements were considered.
Mirsky, W.
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source