Results 51 to 60 of about 842,684 (285)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Testing and evaluation of cold-start emissions from a gasoline engine in RDE test at two different ambient temperatures

Open Engineering, 2021
In order to better reflect the actual ecological performance of vehicles in traffic conditions, both the emission standards and the applied emission tests are being developed, for example by considering exhaust emissions for a cold engine start.
Pielecha Jacek, Skobiej Kinga, Kurtyka Karolina   +2 more
doaj   +1 more source

Development of Two-Step Exhaust Rebreathing for a Low-NOx Light-Duty Gasoline Compression Ignition Engine

Energies, 2022
The global automotive industry is undergoing a significant transition as battery electric vehicles enter the market and diesel sales decline. It is widely recognized that internal combustion engines (ICE) will be needed for transport for years to come ...
Praveen Kumar, Mark Sellnau, Ashish Shah, Christopher Whitney, Rafael Sari   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Switzerland's PM10 and PM2.5 environmental increments show the importance of non-exhaust emissions

Atmospheric Environment: X, 2021
Atmospheric particulate matter (PM) is a priority pollutant for urban air pollution management because of its negative effects on human health and visibility.
Stuart K. Grange, Andrea Fischer, Claudia Zellweger, Andrés Alastuey, Xavier Querol, Jean-Luc Jaffrezo, Samuël Weber, Gaëlle Uzu, Christoph Hueglin   +8 more
doaj   +1 more source

Emission of Carcinogenic Components with Automobile Exhausts

Environmental Health Perspectives, 1983
Different sampling methods for mutagenic polynuclear aromatic hydrocarbons (PAH) are described. These methods involve either direct sampling of raw exhausts which prior to filtering are cooled in a condenser, or filter sampling of exhausts diluted in a tunnel.
U, Stenberg, T, Alsberg, R, Westerholm
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A review of non-exhaust emissions on pavement area: Sources, compositions, evaluation and mitigation

Journal of Traffic and Transportation Engineering (English ed. Online)
Particulate matter (PM) in outdoor air pollution is one of the most critical factors that cause serious health problems and even deaths. One significant source of these particles are non-exhaust emissions, which refer to pollutants that come from sources,
Chuan He, Wei Jiang, Qingyi Xiao, Chengwei Xing, Dongdong Yuan, Rong Lu, Wangjie Wu   +6 more
doaj   +1 more source

How Technological Innovation Influences Environmental Pollution: Evidence from China

Complexity, 2022
Technological innovation has an important impact on environmental pollution. In this paper, first, we analyze the influence mechanism of technological innovation on environmental pollution and then design the index system of technological innovation ...
Duan Xin, Zhang Zhi Sheng, Sun Jiahui
doaj   +1 more source