Results 101 to 110 of about 271,644 (312)

NK Cell Exhaustion [PDF]

, 2017
Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense.
Zhigang Tian, Jiacheng Bi
core   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Choosing T-cell sources determines CAR-T cell activity in neuroblastoma

Frontiers in Immunology
IntroductionThe clinical success of chimeric antigen receptor-modified T cells (CAR-T cells) for hematological malignancies has not been reproduced for solid tumors, partly due to the lack of cancer-type specific antigens.
Lorena García-García, Lorena García-García, Elena G. Sánchez, Elena G. Sánchez, Mariya Ivanova, Mariya Ivanova, Keren Pastora, Keren Pastora, Cristina Alcántara-Sánchez, Cristina Alcántara-Sánchez, Jorge García-Martínez, Jorge García-Martínez, Beatriz Martín-Antonio, Manuel Ramírez, Manuel Ramírez, Manuel Ramírez, África González-Murillo, África González-Murillo, África González-Murillo   +18 more
doaj   +1 more source

Microfabricated Anisotropic Myobundles for the Scalable Production of Cardiac Tissue Grafts

Advanced Functional Materials, EarlyView.
Controlling the anisotropy of cardiac tissue remains an outstanding challenge in the field of cardiac tissue engineering. Here, we introduce an approach to generate anisotropic cardiac myobundles using cell‐adhesive, synthetic, electrospun fibers and stem cell‐derived cardiac fibroblasts.
Maggie E. Jewett, Javiera Jilberto, Margaret E. Stanley, David O. Ntim, Siddhi M. Bhirud, Avianna T. Schroeder, Gonzola X. Anyosa Galvez, Jingyi Xia, Samuel J. DePalma, Emmanouil Agrafiotis, Susan S. Xi, Amanda S. Bluem, Courtney M. Lestock, Adam S. Helms, David A. Nordsletten, Brendon M. Baker   +15 more
wiley   +1 more source

Association of Physicians’ Self-Compassion with Work Engagement, Exhaustion, and Professional Life Satisfaction

, 2019
Self-compassion has shown promise as an adaptive resource for coping with uncertainties and challenges. This study examined the relationship between self-compassion and professional wellbeing (work engagement, exhaustion, and professional life ...
Babenko, Oksana, Lee, Ann, Koppula, Sudha, Mosewich, Amber   +3 more
core   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation

Frontiers in Immunology
IntroductionAtherosclerosis is a lipid-driven inflammatory disease of the arterial wall, and the underlying cause of the majority of cardiovascular diseases.
Winnie G. Vos, Winnie G. Vos, Winnie G. Vos, Bram W. van Os, Bram W. van Os, Bram W. van Os, Myrthe den Toom, Linda Beckers, Cindy P.A.A. van Roomen, Claudia M. van Tiel, Bhopal C. Mohapatra, Hamid Band, Katrin Nitz, Katrin Nitz, Katrin Nitz, Christian Weber, Christian Weber, Christian Weber, Christian Weber, Dorothee Atzler, Dorothee Atzler, Dorothee Atzler, Menno P.J. de Winther, Menno P.J. de Winther, Menno P.J. de Winther, Laura A. Bosmans, Laura A. Bosmans, Laura A. Bosmans, Esther Lutgens, Esther Lutgens, Esther Lutgens, Tom T.P. Seijkens, Tom T.P. Seijkens, Tom T.P. Seijkens   +33 more
doaj   +1 more source

First Sale and Exhaustion

, 2020
This chapter in the forthcoming case book Intellectual Property Licensing and Transactions: Theory and Practice addresses issues of first sale and exhaustion for licensing transactions involving patents, copyrights and trademarks.
Contreras, Jorge L.
core  

Hyperventilation and exhaustion syndrome

, 2013
Chronic stress is among the most common diagnoses in Sweden, most commonly in the form of exhaustion syndrome (ICD-10 classification - F43.8). The majority of patients with this syndrome also have disturbed breathing (hyperventilation).
Emtner, Margareta, Ristiniemi, Heli,, Emtner, Margareta,, Ristiniemi, Heli, Lyskov, Eugene, Eugene Lyskov, Perski, Aleksander, Heli Ristiniemi, Aleksander Perski, Lyskov, Eugene,, Margareta Emtner, Perski, Aleksander,   +11 more
core   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source