Results 81 to 90 of about 321,704 (306)

Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion

open access: yesFrontiers in Immunology
BackgroundAnti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has proven effective for treating relapsed or refractory acute B cell leukemia.
Shufeng Xie   +17 more
doaj   +1 more source

The Poetics and Politics of Interruption in the 2020-21 Belarus Uprising

open access: yesAtlantis, 2023
The paper addresses the notions of interruption and exhaustion in relation to the 2020–21 anti-governmental uprising in Belarus. It examines various forms of protesting, such as marches, neighbourhood gatherings and strikes from a feminist perspective ...
Olia Sosnovskaya
doaj  

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay   +15 more
wiley   +1 more source

Exhaustion of trademark rights

open access: yes, 2009
The thesis deals with the analysis of exhaustion of trade mark rights, it focuses mainly on the comunnity-wide exhaustion. It is based mainly on the interpretation of the case law of the European Court of Justice which is used both to describe the ...
Hýžová, Zuzana
core   +1 more source

Reducing Emotional Exhaustion and Increasing Organizational Support [PDF]

open access: yes, 2011
Purpose: The purpose of this study is to explore stressors that may influence salespersons' emotional exhaustion and their perception of organizational support.
Boles, James S.   +1 more
core  

Can empathy lead to emotional exhaustion in teachers? The mediating role of emotional labor [PDF]

open access: yes, 2013
Objectives: The present study was designed to examine the links between empathy, emotional labor (both surface and deep acting), and emotional exhaustion as well as determine if emotional labor mediates the relationship between empathy and emotional ...
Wróbel, Monika, Monika Wróbel
core   +2 more sources

Stage‐Specific Patterns of Imaging and Non‐Motor Biomarkers in Spinocerebellar Ataxia Type 3

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Advancements in disease‐modifying therapies for spinocerebellar ataxia Type 3 (SCA3) underscore the need for robust biomarkers to monitor disease progression and evaluate treatment efficacy. Although motor phenotypes have been well characterized, less is known about non‐motor and imaging‐based features across different disease stages.
Chun Li   +17 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

open access: yesArthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos   +2 more
wiley   +1 more source

Exhaustion of Leisure: Identity and Cycling

open access: yes, 2014
Finn Kolsrud examines amateur bicycling from a sociological perspective, relying on interviews and the concepts of exhaustion and flow. Kolsrud’s project examines the ways that the drive to compete gets mixed with the drive to get ahead.
Finn Kolsrud
core  

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

open access: yesArthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo   +6 more
wiley   +1 more source

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