Results 131 to 140 of about 604,131 (324)

Choosing T-cell sources determines CAR-T cell activity in neuroblastoma

Frontiers in Immunology
IntroductionThe clinical success of chimeric antigen receptor-modified T cells (CAR-T cells) for hematological malignancies has not been reproduced for solid tumors, partly due to the lack of cancer-type specific antigens.
Lorena García-García, Lorena García-García, Elena G. Sánchez, Elena G. Sánchez, Mariya Ivanova, Mariya Ivanova, Keren Pastora, Keren Pastora, Cristina Alcántara-Sánchez, Cristina Alcántara-Sánchez, Jorge García-Martínez, Jorge García-Martínez, Beatriz Martín-Antonio, Manuel Ramírez, Manuel Ramírez, Manuel Ramírez, África González-Murillo, África González-Murillo, África González-Murillo   +18 more
doaj   +1 more source

Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering

Advanced Healthcare Materials, EarlyView.
This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer, Arundhati Joshi, Constantin von Kaisenberg, Dorothea Brüggemann, Cornelia Lee‐Thedieck   +4 more
wiley   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

Introduction

Études Britanniques Contemporaines, 2012
Isabelle Gadoin, Catherine Lanone
doaj   +1 more source

T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation

Frontiers in Immunology
IntroductionAtherosclerosis is a lipid-driven inflammatory disease of the arterial wall, and the underlying cause of the majority of cardiovascular diseases.
Winnie G. Vos, Winnie G. Vos, Winnie G. Vos, Bram W. van Os, Bram W. van Os, Bram W. van Os, Myrthe den Toom, Linda Beckers, Cindy P.A.A. van Roomen, Claudia M. van Tiel, Bhopal C. Mohapatra, Hamid Band, Katrin Nitz, Katrin Nitz, Katrin Nitz, Christian Weber, Christian Weber, Christian Weber, Christian Weber, Dorothee Atzler, Dorothee Atzler, Dorothee Atzler, Menno P.J. de Winther, Menno P.J. de Winther, Menno P.J. de Winther, Laura A. Bosmans, Laura A. Bosmans, Laura A. Bosmans, Esther Lutgens, Esther Lutgens, Esther Lutgens, Tom T.P. Seijkens, Tom T.P. Seijkens, Tom T.P. Seijkens   +33 more
doaj   +1 more source

When is it Optimal to Exhaust a Resource in a Finite Time? [PDF]

Exhaustion of a natural resource stock may be a rational choice for an individual and/or a community, even if a sustainable use for the resource is feasible and the resource users are farsighted and well informed on the ecosystem.
Ken-Ichi Akao, Y. Hossein Farzin
core  

SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment

, 2020
Patrick M. O’Connell, Sean Hyslop, Maja K. Blake, Sarah Godbehere, Andrea Amalfitano, Yasser A. Aldhamen   +5 more
openalex   +2 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Start, Stop, Rewind, Repeat—Cyclic Exposure of Adipose Stromal Cells‐derived Cartilage Organoids to Chondrogenic and Proliferative Cues to Achieve Scaled‐up and Customizable Bone Formation by Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
This study exploits the plasticity of ASCs‐derived cartilage organoids which generate a perichondrial layer of MSCs when exposed to cyclic chondrogenic/proliferative cues. Using these organoids as building blocks, we develop (i) Phalange Shaped Tissue Engineered Cartilage (Pa‐TECs), recapitulating endochondral ossification suitable for the treatment of
Pablo Pfister, Emilien Lhospice, Andrés García‐García, Robert Paillaud, Sebastian Jung, Romain Schaller, Elisabeth A. Kappos, Claude Jaquiéry, Tarek Ismail, Dirk J. Schaefer, Michael de Wild, Ivan Martin, Alexandre Kaempfen, Arnaud Scherberich, Adrien Moya   +14 more
wiley   +1 more source

BIOMECHANICAL, COORDINATIVE, AND PHYSIOLOGICAL RESPONSES TO A TIME-TO-EXHAUSTION PROTOCOL AT TWO SUBMAXIMAL INTENSITIES IN SWIMMING

, 2019
Marcos Franken, Pedro Figueiredo, Ricardo Peterson Silveira, Flávio Antônio de Souza Castro   +3 more
openalex   +2 more sources