Results 201 to 210 of about 602,474 (294)

ITK-targeted immune remodeling enhanced the efficacy of anti-CD19 CAR-T cell therapy. [PDF]

Cell Death Discov
Li Z, Lv L, Yao X, Feng Z, Xie Y, Li K, Qi F, Yang M, Wang J, Pan T, Li X, Chen H, Wang J, Ding Y, Zhu J, Song Y, Wang X, Ding N.   +17 more
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Contrasting functions of CD73 and adenosine in CD8+ T-cell exhaustion during antitumor immunity. [PDF]

Oncoimmunology
Saavedra-Almarza J, Gouët S, Malgue F, Bascuñan C, Hernández-Oliveras A, De la Rosa J, Reyes-Alvarez J, Villaman C, Corrales-Bermúdez J, Castañeda J, García-Gómez M, Martin AJM, Lladser Á, Rosemblatt M, Bono MR, Sauma D.   +15 more
europepmc   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Eidelson v. Archer: Exhaustion of Remedies in a Private Hospital [PDF]

, 1984
Aviles, Karen A.
core   +1 more source

The dual pathways of emotional labor in psychiatric nursing: the adaptive and maladaptive emotional strategies. [PDF]

Front Psychiatry
Huang G, Zheng Y, Shen G, Wang H, Wang L.   +4 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Patent Exhaustion and the Federal Circuit’s Deviant Conditional Sale Doctrine: Bowman v. Monsanto [PDF]

, 2013
Garmezy, Adam
core   +1 more source

T cell fate regulation in EBV‑associated nasopharyngeal carcinoma (Review). [PDF]

Oncol Rep
Zhang L, Ding S, Chen D, Cai B, Mu Z.
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source