Results 181 to 190 of about 271,644 (312)

Inverse relationship between neoantigen clonality and T-cell activity reveals distinct immune phenotypes in HNSCC. [PDF]

J Transl Med
Saravi B, Singh DD, Schorn L, Lommen J, Schrader F, Wilkat M, Vollmer A, Vollmer M, Hartmann S, Hörner M, Adhikari K, Roider E, Wollborn J, Kübler N, Sproll C.   +14 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Relationship Between Self-Efficacy and Burnout Syndrome in Resident Physicians in Metropolitan Lima. [PDF]

Int J Environ Res Public Health
Sulca Quispe RE, Moncada DV, Francia FTJ.   +2 more
europepmc   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

How leader-enforced positivity and humility-aspiration signaling shape emotional exhaustion and unethical behavior: evidence for distinct psychological pathways. [PDF]

Front Psychol
Ali H, Zheng R, Meng L, Qasim M.
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

T cell exhaustion landscapes and therapeutic modulation in cancer immunity. [PDF]

Front Cell Dev Biol
Bautista J, López-Cortés A.
europepmc   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Relieving or Aggravating? The Longitudinal Moderating Role of Challenge and Hindrance Academic Stressors on the Relationship Between Leisure-Time Physical Activity and Context-Specific Anxiety Symptoms Among University Faculty. [PDF]

Behav Sci (Basel)
Li H, Shi M, Zhu Q.
europepmc   +1 more source

Managing Resilience and Exhaustion Among Health Care Workers Through Psychological Self-Care: The Impact of Job Autonomy in Interaction With Role Overload

Francis Maisonneuve,1 Anaïs Galy,1 Patrick Groulx,2 Denis Chênevert,1 Colleen Grady,3 Angela M Coderre-Ball3 1Department of Human Resources Management, HEC Montréal, Montréal, QC, Canada; 2Department of Organisations and Human Resources, ESG UQAM ...
Chênevert D, Grady C, Maisonneuve F, Galy A, Coderre-Ball AM, Groulx P   +5 more
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