Results 51 to 60 of about 1,131 (215)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Artificial intelligence empowering museum space layout design: Insights from China.

PLoS ONE
The floor plan layout of museum exhibition spaces is the skeleton network of the museum, which determines the internal circulation and spatial form of the museum.
Qiang Tang, Liang Zheng, Yile Chen, Lina Yan, Junzhang Chen   +4 more
doaj   +1 more source

Visual-Guidance Interventions for Child Pedestrian Behavior: An Empirical Study Employing Multimodal Experiments

Applied Sciences
As urbanization accelerates, children’s safety when crossing urban streets has become an increasingly prominent concern. However, current street designs and visual guidance facilities are largely configured around adult users and tend to overlook ...
Wenjie Peng, Xinyu Zhang, Bingmiao Zhu, Shimeng Hao, Quan Jing   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Exhibiting Design

Calenda, 2022
Appel à contributions pour la cinquième édition de RADDAR (Revue annuelle de design) sur le thème Exposer le design. RADDAR est une revue thématique et bilingue de recherche en design, coéditée par le mudac (Musée cantonal de design et d’arts appliqués contemporains, Lausanne) et T&P Work UNit, Paris.
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

GazeNet: Neural Network-Based Visual Attention Simulation for Museum Exhibition Optimization

IEEE Access
Effective visual communication in cultural heritage exhibitions requires strategic organization of information elements to guide visitor attention and enhance learning outcomes.
Chunyan Tian, Shen You, Wei Wang
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Entre soin et réemploi : vers une idée de scénographie durable avec Home Sweet Home

Culture & Musées
In the face of the climate emergency and the need for an ecological transition, the transformation of the cultural sectors requires a deep overhaul of operating modes and professional practices, especially in the field of exhibition design. This piece of
Chiara Rubessi
doaj   +1 more source