Results 91 to 100 of about 203,466 (305)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cauriensia, 2014 Con motivo del Año Eucarístico Internacional la diócesis de Coria-Cáceres organizó una exposición titulada Verum Corpus. El autor nos propone un recorrido a través de la reflexión que animó dicha exposición en torno a las salas y estancias que la ...
José Antonio Fuentes Caballero
doaj +2 more sources
Automatic monitoring and control of museums’ environment based on Wireless Sensor Networks
Electronic Journal of Structural Engineering, 2010 In museums, it is critical to properly conserve the existing artwork. For this purpose, it is fundamental to continuously monitor its environment, either in storage or exhibition rooms.
L.M. Rodríguez Peralta +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Spartan Daily, November 22, 2004 [PDF]
, 2004 Volume 123, Issue 59https://scholarworks.sjsu.edu/spartandaily/10063/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Tersicoccus phoenicis (Actinobacteria), a spacecraft clean room isolate, exhibits dormancy
Microbiology SpectrumABSTRACT Space missions or spacecraft equipment destined for sensitive environments, such as Mars, Europa, or Enceladus, are required to be designed to avoid forward contamination. Spacecraft are assembled in clean rooms (SACs) employing treatments to eliminate microbial contamination.
Madhan Tirumalai +3 more
openaire +2 more sources
Giorgione [exhibition review] [PDF]
, 2016 Exhibition review of In the Age of Giorgione (London, Royal Academy of ...
Nichols, Tom
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Warehouse of failed invention [PDF]
, 2012 The exhibition consisted of a new installation work, combined with sculptural and video elements. The space was initially transformed from its 'white cube' architectural state, into a warehouse storage unit.
Selby, Mark
core +1 more source