Results 101 to 110 of about 203,466 (305)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Timetabling in constraint logic programming [PDF]
, 1996 In this paper we describe the timetabling problem and its solvability in a Constraint Logic Programming Language. A solution to the problem has been developed and implemented in ECLiPSe, since it deals with finite domains, it has well-defined ...
Gilbert, D, Kambi, M
core +1 more source
In Situ, 2019 The Louvre today holds an exceptional ensemble of Gobelins tapestries which come from the bed chamber of the Duchess of Bourbon at the Palais-Bourbon.
Frédéric Dassas
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Craig: the forgotten modernist [PDF]
, 2010 This was the keyword speech at the event, 'Edward Gordon Craig: His Legacy' A biographical and historical perspective, this talk suggests some early influences on Craig’s visionary ideas from his extraordinary theatrical pedigree.
Holroyd, Michael
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Reframing Ethnographic Film [PDF]
, 2008 Book description: From a boom in theatrical features to footage posted on websites such as YouTube and Google Video, the early years of the 21st century have witnessed significant changes in the technological, commercial, aesthetic, political, and social
Basu, P
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The musealisation of the artist's house as architectural project [PDF]
, 2011 Artist’s houses that are opened to the public as museums shift from a private and everyday to a semi-public and institutional functioning. This transformation of an artist’s house into a house-museum might appear as a mere legal issue or as a matter of ...
Liefooghe, Maarten
core
Model Based Control of Moisture Sorption in a Historical Interior
Acta Polytechnica, 2005 This paper deals with a novel scheme for microclimate control in historical exhibition rooms, inhibiting moisture sorption phenomena that are inadmissible from the preventive conservation point of view.
P. Zítek, T. Vyhlídal
doaj