Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
From Learning to Rationalization: the Roles of Accounting in the Management of Parisian Great Exhibitions from 1853 to 1902 [PDF]
During the second half of the nineteenth century, five Great Exhibitions took place in Paris. The French state was highly involved in their financing and management which led to the implementation of public finance rules.
Céline Michaïlesco, Karine Fabre
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Excavating Identity: The Significance of Soil Exhibitions for Understanding Place
Exhibition design, as a powerful medium of communication and interpretation, can reveal the hidden richness and regional identity embedded within the subterranean layers of soil.
Jacqueline McIntosh +3 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Countering a Legal Threat to Cultural Exchanges of Works of Art: The Malewicz Case and Proposed Remedies [PDF]
The ability of U.S. museums to borrow for exhibition works of art from museums owned by foreign governments is seriously threatened under a ruling of the Federal District Court for the District of Columbia in the case of Malewicz v.
Marion R. Fremont-Smith +2 more
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Museos y arqueología: feminismo para cambiar los discursos [PDF]
En este trabajo se plantea la necesidad de cambiar los discursos museológicos hegemónicos y androcéntricos que muchos museos de arqueología aún mantienen.
Begoña Soler Mayor
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The Asian mango flower beetle, Protaetia fusca (Herbst), and Euphoria sepulcralis (Fabricius) in Florida and the West Indies (Coleoptera: Scarabaeidae: Cetoniinae) [PDF]
The mango flower beetle, Protaetia fusca (Herbst), an Asiatic pest of several commercial crops, was first found in Florida in 1985. All subsequent Florida specimens are recorded here, as well as the first documented records from the Bahamas and Barbados.
Woodruff, Robert E.
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