Results 111 to 120 of about 3,025,019 (314)

Positive solutions for a class of singular boundary-value problems

Electronic Journal of Differential Equations, 2007
Using regularization and the sub-super solutions method, this note shows the existence of positive solutions for singular differential equation subject to four-point boundary conditions.
Li Xia, Zhengan Yao
doaj  

Existence of Solutions for a Hadamard Fractional Boundary Value Problem at Resonance

Fractal and Fractional
We explore the existence of solutions for a Hadamard fractional differential equation, subject to nonlocal boundary conditions, which contain Hadamard fractional derivatives and Riemann–Stieltjes integrals.
Rodica Luca, Alexandru Tudorache
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Global conservation of phylogenetic diversity captures more than just functional diversity

Nature Communications, 2019
Nisha R. Owen, Rikki Gumbs, Claudia L. Gray, Daniel P. Faith   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Existence and Stability of Neutral Stochastic Impulsive and Delayed Integro-Differential System via Resolvent Operator

Fractal and Fractional
In this paper, we present the existence of a mild solution for a class of a neutral stochastic integro-differential system over a Hilbert space. Such systems are influenced by both multiplicative and fractional noise, alongside non-instantaneous impulses,
Hamza Khalil, Akbar Zada, Mohamed Rhaima, Ioan-Lucian Popa   +3 more
doaj   +1 more source

On the existence and functionality of topologically associating domains

Nature Genetics, 2020
J. Beagan, Jennifer E. Phillips-Cremins
semanticscholar   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

THE EXISTENCE OF GOD

Philosophical Books, 1965
Why believe that there is a God at all? My answer is that to suppose that there is a God explains why there is a physical universe at all; why there are the scientific laws there are; why animals and then human beings have evolved; why humans have the opportunity to mould their characters and those of their fellow humans for good or ill and to change ...
openaire   +2 more sources