Results 111 to 120 of about 2,776,395 (308)

A New Existence and Uniqueness Theorem for Continuous Games [PDF]

open access: yes
This paper derives a general sufficient condition for existence and uniqueness in continuous games using a variant of the contraction mapping theorem applied to mapping from a subset of the real line on to itself.
Seamus Hogan
core  

Existence of solutions for nonlinear parabolic problems [PDF]

open access: yes, 1999
summary:We consider nonlinear parabolic boundary value problems. First we assume that the right hand side term is discontinuous and nonmonotone and in order to have an existence theory we pass to a multivalued version by filling in the gaps at the ...
Papageorgiou, N   +3 more
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

On a Class of Nonlinear Elliptic Equations with General Growth in the Gradient

open access: yesMathematics
In this paper, we prove an existence and uniqueness result for a class of Dirichlet boundary value problems whose model is −Δpu=β|∇u|q+c|u|p−2u+fin Ω,u=0on ∂Ω, where Ω is an open bounded subset of RN, N≥2 ...
M. Francesca Betta   +2 more
doaj   +1 more source

Boundary value problems for differential equations with reflection of the argument

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1985
Linear and nonlinear boundary value problems for differential equations with reflection of the argument are considered.
Joseph Wiener, A. R. Aftabizadeh
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Existence of competitive equilibrium in an optimal growth model with heterogeneous agents and endogenous leisure [PDF]

open access: yes
This paper proves the existence of competitive equilibrium in a single-sector dynamic economy with heterogeneous agents, elastic labor supply and complete assets markets.
Aditya Goenka   +2 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

On the existence of Berge's strong equilibrium [PDF]

open access: yes
In this paper, we establish the existence of Berge's strong equilibrium for games with n persons in infinite dimensional strategy spaces in the case where the payoff function of each player is quasi-concave.
Monique Florenzano, Messaoud Deghdak
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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