Results 151 to 160 of about 8,161,835 (383)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Existence and non existence of capillary surfaces

open access: yesManuscripta Mathematica, 1979
A general criterion for existence of solutions of the capillary equation, introduced by Concus and Finn [1] and by Giusti [7], is shown to be equivalent to the question of existence of certain vector fields. The result is applied to particular boundary configurations, and it is shown that in some cases the local “corner condition” of [1] is both ...
openaire   +2 more sources

Foreword: Speaking Existence [PDF]

open access: yes
[[issue ...
Joan Chiung-huei Chang   +1 more
core  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

On the existence and functionality of topologically associating domains

open access: yesNature Genetics, 2020
Jonathan A. Beagan   +1 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

On existence theorems

open access: yesDiscrete Mathematics, 1993
AbstractWe discuss the question of constructive proofs, or polynomial-time algorithms, for theorems which were proved earlier nonconstructively. We present a formal model for such statements and give a collection of examples. In a greater detail, we deal with the problem of finding another Hamiltonian cycle in a cubic graph provided that one cycle is ...
openaire   +2 more sources

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