Results 61 to 70 of about 8,161,835 (383)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Kimboza, a Small Lowland Forest With an Outstanding Herpetofauna Diversity in East Africa
Ecology and EvolutionThe Eastern Arc Mountains (EAM) and Coastal forests of Tanzania are renowned for harboring large number of threatened and endemic vertebrate species, yet most of these areas have been partially studied. The Kimboza Nature Forest Reserve (KNFR) is a small
John V. Lyakurwa +5 more
doaj +1 more source
AIMS Mathematics, 2019 In this paper, we discuss the existence and uniqueness of solutions for a new kind of Langevin equation involving Riemann-Liouville as well as Caputo fractional derivatives, and variable coefficient, supplemented with nonlocal-terminal fractional integro-
Bashir Ahmad +2 more
doaj +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Historical fire regimes in whitebark pine ecosystems of west‐central British Columbia
EcosphereForest ecosystems across western North America are experiencing increasingly large and severe wildfire disturbances. From 2012 to 2024, approximately 600,000 ha of forest in Tweedsmuir Provincial Park, British Columbia's largest protected area, were ...
Kira M. Hoffman +2 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
, 2017 Everything is in motion. "Inertness" arises from (approximative) repetition, that is, through rotation or an alternation that delineates a focus of consciousness. This focus of consciousness, in turn, must also move/alternate (the two differ only in continuity).
openaire +11 more sources
AIMS Mathematics, 2022 In this article, we propose some novel results on the existence and uniqueness of generalized Caputo-type initial value problems with delay by using fixed point theory.
Pushpendra Kumar +2 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
On well posed impulsive boundary value problems for p(t)-Laplacian's
Mathematical Modelling and Analysis, 2013 In this paper we investigate via variational methods and critical point theory the existence of solutions, uniqueness and continuous dependence on parameters to impulsive problems with a p(t)-Laplacian and Dirichlet boundary value conditions.
Marek Galewski, Donal O'Regan
doaj +1 more source