Results 171 to 180 of about 201,556 (360)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Existence and uniqueness of the p-generalized modified error function

Electronic Journal of Differential Equations, 2020
In this article, we define a p-generalized modified error function as the solution to a non-linear ordinary differential equation of second order, with a Robin type boundary condition at x=0.
Julieta Bollati, Jose A. Semitiel, Maria F. Natale, Domingo A. Tarzia   +3 more
doaj  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Study on existence and stability analysis for implicit neutral fractional differential equations of ABC derivative

Partial Differential Equations in Applied Mathematics
In this paper, we study the existence, uniqueness, and stability analysis of non-linear implicit neutral fractional differential equations involving the Atangana–Baleanu derivative in the Caputo sense. The Banach contraction principle theorem is employed
V. Sowbakiya, R. Nirmalkumar, K. Loganathan, C. Selvamani   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Existence and uniqueness of solutions for nonlocal p-Laplacian problems

Electronic Journal of Differential Equations, 2016
We study the existence and uniqueness of positive solutions to a class of nonlocal boundary-value problems involving the p-Laplacian. Our main tools are a variant of the Schaefer's fixed point theorem, an inequality which suitably handles the p ...
Behrouz Emamizadeh, Amin Farjudian
doaj  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Asset pricing with time preference shocks: Existence and uniqueness [PDF]

This paper studies existence and uniqueness of recursive utility in asset pricing models with time preference shocks. We provide conditions that clarify existence and uniqueness for a wide range of models, including exact necessary and sufficient ...
Wilms, Ole; id_orcid, Stachurski, John, Zhang, Junnan   +2 more
core   +1 more source

Existence and uniqueness for a p-Laplacian nonlinear eigenvalue problem

Electronic Journal of Differential Equations, 2010
We consider the Dirichlet eigenvalue problem $$ -mathop{ m div}(| abla u|^{p-2} abla u ) =lambda | u|_q^{p-q}|u|^{q-2}u, $$ where the unknowns $uin W^{1,p}_0(Omega )$ (the eigenfunction) and $lambda >0$ (the eigenvalue), $Omega $ is an arbitrary ...
Giovanni Franzina, Pier Domenico Lamberti   +1 more
doaj