Results 151 to 160 of about 201,556 (360)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
On the Existence of Pure Strategy Nash Equilibria in Integer-Splittable Weighted Congestion Games [PDF]
, 2011 We study the existence of pure strategy Nash equilibria (PSNE) in integer–splittable weighted congestion games (ISWCGs), where agents can strategically assign different amounts of demand to different resources, but must distribute this demand in fixed ...
Polukarov, Maria +9 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Independence, Heterogeneity and Uniqueness in Interaction Games [PDF]
This paper shows that incomplete information and sufficient heterogeneity of players can ensure uniqueness in interaction games. In contrast to recent work on uniqueness in interaction games, we do not require strategic complementarity.
Robin Mason, Akos Valentinyi
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Some remarks about uniquenes of equilibrium for infinite dimensional economies [PDF]
For economies with infinitely many goods, with two different approaches we obtain sufficient conditions for uniqueness of competitive equilibrium. In the second approach we prove that the Mitjushim-Polterovich conditions is a sufficient condition for ...
Elvio Accinelli
core
Existence and uniqueness of a fixed point for local contractions [PDF]
, 2010 This paper proves the existence and uniqueness of a fixed point for local contractions without assuming the family of contraction coefficients to be uniformly bounded away from 1.
Martins-da-Rocha, V.F., Vailakis, Y.
core +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Unicidad del equilibrio de Nash-Cournot con correspondencias de mejor respuesta contractivas [PDF]
In this work we obtain new conditions to uniqueness of Nash equilibrium in the Cournot oligopoly model. These conditions assure that the reaction functions are contractions and they are not reduced to the obtained ones by Rosen, inasmuch as they do not ...
Edgar Carrera, Elvio Accinelli
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source