Results 131 to 140 of about 55,115 (257)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Existence and uniqueness of well-posed fractional boundary value problem.

PLoS ONE
In this paper, the existence and uniqueness of solution for a fractional differential model involving well-posed boundary conditions and implicit fractional differential equation is considered.
Yuanheng Wang, Barrira Jurrat, Muddasir Ejaz, Muhammad Azeem, M I Elashiry   +4 more
doaj   +1 more source

Study on existence and stability analysis for implicit neutral fractional differential equations of ABC derivative

Partial Differential Equations in Applied Mathematics
In this paper, we study the existence, uniqueness, and stability analysis of non-linear implicit neutral fractional differential equations involving the Atangana–Baleanu derivative in the Caputo sense. The Banach contraction principle theorem is employed
V. Sowbakiya, R. Nirmalkumar, K. Loganathan, C. Selvamani   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Existence and uniqueness of maximal solutions to SPDEs with applications to viscous fluid equations

We present two criteria for the existence and uniqueness of a maximal strong solution for a general class of stochastic partial differential equations. Each criterion has its corresponding set of assumptions and can be applied to viscous fluid equations ...
Crisan, Dan, Goodair, Daniel, Lang, Oana
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Existence and uniqueness of solutions for nonlocal p-Laplacian problems

Electronic Journal of Differential Equations, 2016
We study the existence and uniqueness of positive solutions to a class of nonlocal boundary-value problems involving the p-Laplacian. Our main tools are a variant of the Schaefer's fixed point theorem, an inequality which suitably handles the p ...
Behrouz Emamizadeh, Amin Farjudian
doaj  

Existence of Solutions to Fractional Differential Equations with Mixed Caputo–Riemann Derivative

Fractal and Fractional
The study of fractional differential equations is gaining increasing significance due to their wide-ranging applications across various fields. Different methods, including fixed-point theory, variational approaches, and the lower and upper solutions ...
Mahir Almatarneh, Sonuc Zorlu, Nazim I. Mahmudov   +2 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source