Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
International Trade and Cournot Equilibrium: Existence, Uniqueness and Comparative Statics [PDF]
, 2018 This paper proves the existence and uniqueness of Cournot equilibrium in models of international trade under oligopoly. The existence of Cournot equilibrium is established without the usual assumption that profit functions are concave.
Collie, David
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Existence and Uniqueness of a Fixed-Point for Local Contractions [PDF]
This paper proves the existence and uniqueness of a fixed-point for local contractions without assuming the family of contraction coefficients to be uniformly bounded away from 1.
Vailakis, Yiannis +1 more
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Positive solutions of nonlinear fourth-order boundary-value problems with local and non-local boundary conditions [PDF]
, 2008 We establish new existence results for multiple positive solutions of fourth-order nonlinear equations which model deflections of an elastic beam. We consider the widely studied boundary conditions corresponding to clamped and hinged ends and many non ...
J. R. L. Webb +5 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
An energetic material model for time-dependent ferroelectric behaviour: existence and uniqueness [PDF]
, 2006 We discuss rate-independent engineering models for the multi-dimensional behaviour of ferroelectric materials. These models capture the non-linear and hysteretic behaviour of such materials.
Timofte, Aida, Mielke, Alexander
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The existence and uniqueness of monotone pure strategy equilibrium in Bayesian games [PDF]
This paper provides a sufficient condition for existence and uniqueness of equilibrium, which is in monotone pure strategies, in games of incomplete information.
Valentinyi, Ãkos, Mason, Robin
core
Nonlinear Critical Elliptic Problems: Existence and Uniqueness [PDF]
, 2023 In this thesis, I shall study the existence, local uniqueness and other related subjects for the bubbling solutions of two elliptic problems involving critical Sobolev ...
Li, Benniao, Du, Yihong
core