Results 161 to 170 of about 10,341 (216)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

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Existence of solutions and existence of optimal solutions. The quasi linear case

Rendiconti del Circolo Matematico di Palermo, 1985
Using Kakutani type fixed point theorems and monotone operator theory in new ways, the authors obtain existence theorems for abstract operator equations which include quasi-linear evolution equations and optimal control problems involving Cauchy-Dirichlet and Cauchy-Neumann equations.
Cesari, L., Hou, S. H.
openaire   +2 more sources

EXISTENCE OF SATISFICING SOLUTIONS

Kybernetes, 1981
As pointed out by Simon, the “satisficing” decision criterion is one of the most fundamental principles which describe human behaviors. Its mathematical representation i.e., a “satisficing” (decision) problem, is specified by Mesarovic as follows. “Find a decision alternative whose performance is equal to or greater than a given aspiration level for ...
Matsuda, T., Takatsu, S.
openaire   +1 more source

Existence of Solutions to a Generalized System

Journal of Optimization Theory and Applications, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kaleem Raza Kazmi, Suhel Ahmad Khan
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The existence of periodic solutions

1999
Abstract Suppose that the phase diagram for a differential equation contains a single, unstable equilibrium point and a limit cycle surrounding it, as in the case of the van der Pol equation. Then in practice all initial states lead to the periodic oscillation represented by the limit cycle.
D W Jordan, P Smith
openaire   +1 more source

Existence of Solutions

2016
In this chapter, we describe and apply two boundary integral equation methods to solve the fundamental boundary value problems formulated in Sect.
Christian Constanda, Dale Doty, William Hamill   +2 more
openaire   +1 more source