Results 31 to 40 of about 29,223 (165)

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Five types of blow-up in a semilinear fourth-order reaction-diffusion equation: an analytic-numerical approach

, 2009
Five types of blow-up patterns that can occur for the 4th-order semilinear parabolic equation of reaction-diffusion type $$ u_t= -\Delta^2 u + |u|^{p-1} u \quad {in} \quad \ren \times (0,T), p>1, \quad \lim_{t \to T^-}\sup_{x \in \ren} |u(x,t)|= +\iy, $
Bakirova M I, Bebernes J, Bricmont J, Dalmasso R, Dold J W, Egorov Yu V, Fefferman C, Frank-Kamenetskii D A, Frank-Kamenetskii D A, Galaktinov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Galaktionov V A, Guo Y, Hamilton R, Herrero M A, Herrero M A, Ibragimov N H, Joulin G Mikishev A B Sivashinsky G I, Kato T, Kurdyumov S P, Kurdyumov S P, Lepin L A, Lepin L A, Leray J, Levitan B M, Loewner C, Lunardi A, Maz'ja V, Mitidieri E, Naimark M A, Nussair E S, Ovsiannikov L V, Pao C V, Peletier L A, Quittner P, Samarskii A A, Semenov N, Svirshchevskii S R, Svirshchevskii S R, Tao T, V A Galaktionov, Velazquez J J L, Zel'dovich Ya B   +52 more
core   +2 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Numerical schemes for the optimal input flow of a supply-chain

, 2012
An innovative numerical technique is presented to adjust the inflow to a supply chain in order to achieve a desired outflow, reducing the costs of inventory, or the goods timing in warehouses.
D'Apice, Ciro, Manzo, Rosanna, Piccoli, Benedetto   +2 more
core   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Multidimensional stochastic differential equations with distributional drift [PDF]

, 2014
This paper investigates a time-dependent multidimensional stochastic differential equation with drift being a distribution in a suitable class of Sobolev spaces with negative derivation order.
Elena Issoglio, Elena Issoglio, Elena Issoglio, Francesco Russo, Francesco Russo, Franco Fl, Franco Fl, Franco Flandoli, Hal Id Hal   +8 more
core   +5 more sources

Optimization of Thermally Radiative and Mass Wavy Flow Analysis Affected by Induced Magnetic Field and Joule Heating

Energy Science &Engineering, EarlyView.
ABSTRACT The role of magnetic induction is declared fundamental in many technological systems, including electric generators, inductors, transformers, and so on. This is an important source for converting energy from one form to another while utilizing electromagnetic induction. This phenomenon is efficient when the induced magnetic field is introduced
Ahmed M. Galal, Latif Ahmad, Saleem Javed, Umair Khan, Nermeen Abdullah, Samia Elattar   +5 more
wiley   +1 more source

Space‐Time Modeling and Numerical Simulations of Non‐Newtonian Fluids Using Internal Variables

International Journal for Numerical Methods in Fluids, EarlyView.
Based on Hamilton's principle, the study focuses on a novel strategy for the modeling of non‐Newtonian fluids with the help of internal variables. Here, the viscosity evolves locally in space and time. Three configurations are numerically implemented, namely channel flow, a benchmark, and a lid‐driven cavity.
Philipp Junker, Thomas Wick
wiley   +1 more source