Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Numerical solutions of neutral stochastic functional differential equations
, 2008 This paper examines the numerical solutions of neutral stochastic functional differential equations (NSFDEs) $d[x(t)-u(x_t)]=f(x_t)dt+g(x_t)dw(t)$, $t\geq 0$.
Wu, Fuke +5 more
core +1 more source
Existence of solutions to a diffusive shallow medium equation. [PDF]
J Evol Equ, 2021 Bögelein V, Dietrich N, Vestberg M.
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Existence of mild solutions on semiinfinite interval for first order differential equation with nonlocal condition [PDF]
, 2000 summary:In this paper we investigate the existence of mild solutions defined on a semiinfinite interval for initial value problems for a differential equation with a nonlocal condition.
Benchohra, M., Ntouyas, S. K.
core
A unified fixed point approach to study the existence of solutions for a class of fractional boundary value problems arising in a chemical graph theory. [PDF]
PLoS One, 2022 Sintunavarat W, Turab A.
europepmc +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Nonlinear perturbations of the Kirchhoff equation
Electronic Journal of Differential Equations, 2017 In this article we study the existence and uniqueness of local solutions for the initial-boundary value problem for the Kirchhoff equation $$\displaylines{ u'' - M(t,\|u(t)\|^{2})\Delta u + |u|^{\rho} =f \quad\text{in } \Omega \times (0, T_0), \cr u=
Manuel Milla Miranda +2 more
doaj
Existence and uniqueness of solutions to singular ODE’s
Archiv der Mathematik, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gorka, Przemyslaw, Rybka, Piotr
openaire +4 more sources