Results 161 to 170 of about 310,792 (316)

Existence and global behavior of solutions to fractional p-Laplacian parabolic problems

Electronic Journal of Differential Equations, 2018
First, we discuss the existence, the uniqueness and the regularity of the weak solution to the following parabolic equation involving the fractional p-Laplacian, $$\displaylines{ u_t+(-\Delta)_{p}^su +g(x,u)= f(x,u)\quad \text{in } Q_T:=\Omega\times (
Jacques Giacomoni, Sweta Tiwari
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Non-existence of black hole solutions for a spherically symmetric, static Einstein-Dirac-Maxwell system

, 1998
We consider for j = 1 2 ; 3 2 ; : : : a spherically symmetric, static system of (2j + 1) Dirac particles, each having total angular momentum j. The Dirac particles interact via a classical gravitational and electromagnetic field.
Felix Finster, Non-existence Black, Hole Solutions Spherically, Joel Smoller, Shing-tung Yau, . . .   +5 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nonstationary Lame system without definite sign energy

Electronic Journal of Differential Equations, 2022
Manuel Milla Miranda, Aldo T. Louredo, Marcondes R. Clark, Giovana Siracusa   +3 more
doaj  

Existence of positive solutions for p(x)-Laplacian problems

Electronic Journal of Differential Equations, 2007
We consider the system of differential equations $$displaylines{ -Delta_{p(x)} u=lambda [g(x)a(u) + f(v)] quadhbox{in }Omegacr -Delta_{q(x)} v=lambda [g(x)b(v) + h(u)] quadhbox{in }Omegacr u=v= 0 quadhox{on } partial Omega }$$ where $p(x) in C ...
Horieh Ghorbani, Ghasem A. Afrouzi
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Existence of solutions to n-dimensional pendulum-like equations

Electronic Journal of Differential Equations, 2004
We study the elliptic boundary-value problem $$displaylines{ Delta u + g(x,u) = p(x) quad hbox{in } Omega cr uig|_{partial Omega} = hbox{ m constant}, quad int_{partialOmega} frac {partial u}{partial u} = 0, }$$ where $g$ is $T$-periodic in $u$, and ...
Maria Cristina Mariani, Pablo L. De Napoli, Pablo Amster   +2 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source