Results 131 to 140 of about 101,859 (316)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Dialectical critical realism and existential phenomenology: a dialogue
, 2005 Coole examines the work of Maurice Merleau-Ponty and his existential phenomenology and arguments regarding the process of dialectical thought; Coole suggests the affinity of this work with critical realism and its relevance to realists.
Coole, Diana
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FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
Necessary and impossible : On existential needs and expressions in relation to induced abortion
, 2009 How do Swedish women cope with induced abortion as a life event? Do existential and spiritual issues have anything to do with women’s psychological and existential wellbeing after an induced abortion? The paper presents material from a pilot study and an
Ekstrand, Maria, +2 more
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Existential War and the Ontological Understanding of Culture
Experiencing Russia’s aggression against Ukraine gives grounds to define culture as a particular world of collective existence; one that is under an existential threat and therefore, this full-scale aggression should be considered a war on cultural world.
Bystrytsky, Yevhen, Yevhen Bystrytsky
core +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
, 2017 Aims: Present results from focus interviews concerning existential aspects related to the adaptation of the WHOQOL-SRPB(BREF) for Swedish adolescents. Background: Exploring existential aspects of HRQL are important when mental ill-health is increasing ...
Melder, Cecilia A, Söderqvist, Fredrik
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Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source