Results 51 to 60 of about 73,884 (294)

Theticity [PDF]

open access: yes, 1996
The subject matter of this chapter is the semantic, syntactic and discoursepragmatic background as well as the cross-linguistic behavior of types of utterance exemplified by the following English sentences […]: (1) My NECK hurts.
Sasse, Hans-Jürgen
core  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Relational parametricity for higher kinds [PDF]

open access: yes, 2012
Reynolds’ notion of relational parametricity has been extremely influential and well studied for polymorphic programming languages and type theories based on System F.
Atkey, Robert
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Negative Indefinite Constructions in Bantu: ‘Nobody’

open access: yesLanguages
This paper presents a first typology of negative indefinites in Bantu languages. The lack of interest in expressions of ‘nobody’ in Bantu languages is connected with the idea that they merely involve a generic noun for ‘person’ and main clause negation ...
Maud Devos   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Variation in the syntax and semantics of predicative possession in Quechua [PDF]

open access: yes, 2018
This paper employs comparative evidence from two closely-related Quechua languages to argue that predicative possession constructions do not always share a single underlying source crosslinguistically (contra Freeze 1992; and in support of Boneh ...
Myler, Neil
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Existential constructions

open access: yes, 2013
Existential constructions are normally defined as sentences in which some entity is associated with some location giving rise to the so-called locative paradigm which also involves the locative and the possessive construction (cf. Freeze 2001). In spite of the apparent simplicity of this approach, the assumption of an allegedly universal locative ...
openaire   +2 more sources

Predicate Nominals and Related Constructions in the Vakh Dialect of Khanty [PDF]

open access: yesLinguistica Uralica
The paper deals with predicate nominals and related constructions in the Vakh dialect of Khanty. They include nominal predicates (which typically express proper inclusion and equation), predicate adjectives, predicate locatives, existentials, possessive,
Sergei V. Kovylin
doaj   +1 more source

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