Results 61 to 70 of about 73,884 (294)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2013 The paper shows that in various sluicing types, the wh-phrase in the sluicing sentence as well as its relatum in the antecedent clause must be F-marked, and it explains this observation with Schwarzschild's (1999) and Merchant's (1999) focus theory ...
Schwabe, Kerstin
core
Automated Synthesis of Dynamically Corrected Quantum Gates [PDF]
, 2012 We address the problem of constructing dynamically corrected gates for non-Markovian open quantum systems in settings where limitations on the available control inputs and/or the presence of control noise make existing analytical approaches unfeasible ...
C. Reutenauer +3 more
core +3 more sources
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Frontiers in Psychology, 2018 The current study focuses on the acquisition of classifier constructions in Hong Kong Sign Language (HKSL) by a group of Deaf children of hearing parents, aided or implanted.
Gladys W. L. Tang, Jia Li
doaj +1 more source
, 2000 Expletives have always been a central topic of theoretical debate and subject to different analyses within the different stages of the Principles and Parameter theory (see Chomsky 1981, 1986, 1995; Lasnik 1992, 1995; Frampton and Gutman 1997; among ...
Sabel, Joachim
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
few notes on the ‘need’ field in Romanian
Bucharest Working Papers in Linguistics, 2010 Isachenko (1974) proposed that in Russian, the absence of a (transitive) verb ‘need’ of the English type (I need a book) correlates with the absence of possessive ‘have’.
Oana Săvescu
doaj
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Presenting and predicating lower events [PDF]
, 2013 The effects of different forms of predication have been insightfully (and almost exclusively) studied for 'simple' cases of predication, of which the 'presentational sentence' is maybe the paradigm instantiation.
Brandt, Patrick
core