Results 101 to 110 of about 48,524 (285)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Influence of the Development History of Nozzle Wall Boundary Layer upon Wave Generation on a Liquid Jet Free Surface

Journal of Fluid Science and Technology, 2009
The relation between the development of the wall boundary layer in a convergent nozzle and free surface waves on the emanated liquid jet has been investigated experimentally.
Kazuhiro ITOH, Hiroshige KUMAMARU
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Design of novel microfluidic concentration gradient generators suitable for linear and exponential concentration ranges

, 2012
A novel microfluidic concentration gradient generator is designed where secondary flow, induced via a surface groove, is used to yield a concentration gradient across the output of the microfluidic device.
Melvin, Tracy, Please, Colin P, Friedrich, Daniel, Melvin, T, Friedrich, D, Please, CP, Please, Colin P., Please, Colin   +7 more
core   +1 more source

Exit without choice: interpretable machine learning unlocks the structural drivers of smallholder dispossession in Pakistan

Agricultural and Food Economics
In Pakistan’s evolving agricultural landscape, smallholder farmers are increasingly exiting farming, not by choice but under structural pressure. This study investigates the underlying associations using an integrated machine learning and econometric ...
Ghazi Abbas, Zhou Ying, Chi Goutai, Qamar Abbas, Khalil El Hindi   +4 more
doaj   +1 more source

Effect of Nozzle Contour on Flow Separation in Overexpanded Rocket Nozzles

Journal of Fluid Science and Technology, 2007
In the present paper, parametric numerical analyses of the separated transonic flows in overexpanded rocket nozzles are conducted. Several types of nozzles are examined numerically to clarify the detailed mechanisms of the occurrence of restricted shock ...
Koichi YONEZAWA, Yukinori YAMASHITA, Yoshinobu TSUJIMOTO, Yasuhide WATANABE, Kazuhiko YOKOTA   +4 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Controlling Seepage Flow Beneath Hydraulic Structures: Effects of Floor Openings and Sheet Pile Wall Cracks

Buildings
Using one opening (filter) within the floors of hydraulic structures is a known technique to relieve the seepage effects on their floors. In this study, a new method to control seepage flow by using two identical filters instead of one was tackled ...
Mohamed Farouk
doaj   +1 more source

Smoluchowski–Kramers approximation and large deviations for infinite-dimensional nongradient systems with applications to the exit problem

The Annals of Probability, 2016
In this paper, we study the quasi-potential for a general class of damped semilinear stochastic wave equations. We show that, as the density of the mass converges to zero, the infimum of the quasi-potential with respect to all possible velocities converges to the quasi-potential of the corresponding stochastic heat equation, that one obtains from the ...
Cerrai, Sandra, Salins, Michael
openaire   +4 more sources