Results 81 to 90 of about 48,524 (285)
Theory of wakefields in a dielectric-filled cavity
Physical Review Special Topics. Accelerators and Beams, 2010 An analytical solution of a wakefield from a charge moving on the axis of a dielectric-filled cylindrical cavity is derived. A solution to the wakefield in a waveguide with only a boundary at the cavity entrance is already known.
J. H. Kim, J. Han, M. Yoon, S. Y. Park
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Interaction of Wnt and SHH gradients synchronizes cell cycle exit and differentiation.
bioRxiv : the preprint server for biologyHow signals coordinate cellular proliferation with differentiation to regulate cell fate transitions is poorly understood. Hair follicle dermal condensates (DCs) emerge in developing skin from an acute cell fate transition in which cell cycle exit and molecular differentiation occur simultaneously.
Li, Ruiqi +12 more
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Stopping Rules for Gradient Methods for Non-Convex Problems with Additive Noise in Gradient
, 2022 We study the gradient method under the assumption that an additively inexact gradient is available for, generally speaking, non-convex problems. The non-convexity of the objective function, as well as the use of an inexactness specified gradient at ...
Polyak, Boris T. +2 more
core
Simulation of flow through dam foundation by isogeometric method
Engineering Science and Technology, an International Journal, 2015 This research introduces a numerical approach called IsoGeometric Analysis (IGA) to solve the Laplace equation. Non-Uniform Rational B-Splines (NURBS) basis function is applied for approximation of the anisotropic saturated porous media of dam foundation
Mehrdad Shahrbanozadeh +2 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Exit of cholesterol from StAR as studied by steered MD simulations.
, 2013 StAR protein is shown as a ribbons model colored in a rainbow gradient from the amino terminus in blue to carboxy terminus in red. The A174–V179 loop that was observed to move and make way for the exit of cholesterol is shown in grey.
María Clemente (350725) +9 more
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FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source