Results 81 to 90 of about 216,543 (287)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A volume-of-fluid formulation for the study of co-flowing fluids governed by the Hele-Shaw equations
, 2013 We present a computational framework to address the flow of two immiscible viscous liquids which co-flow into a shallow rectangular container at one side, and flow out into a holding container at the opposite side.
Afkhami, Shahriar, Renardy, Yuriko
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Simulation of flow through dam foundation by isogeometric method
Engineering Science and Technology, an International Journal, 2015 This research introduces a numerical approach called IsoGeometric Analysis (IGA) to solve the Laplace equation. Non-Uniform Rational B-Splines (NURBS) basis function is applied for approximation of the anisotropic saturated porous media of dam foundation
Mehrdad Shahrbanozadeh +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Quasi-potential landscape in complex multi-stable systems
, 2012 Developmental dynamics of multicellular organism is a process that takes place in a multi-stable system in which each attractor state represents a cell type and attractor transitions correspond to cell differentiation paths.
Aliyu, M. D. S. +3 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
End-wall boundary layer measurements in a two-stage fan [PDF]
Detailed flow measurements made in the casing boundary layer of a two-stage transonic fan are summarized. These measurements were taken at a station upstream of the fan, between all blade rows, and downstream of the last row.
Ball, C. L., Reid, L., Schmidt, J. F.
core +1 more source
Laboratory Study on the Effects of Exit Face Inclination of Critical Gradients
, 2015 The objective of this research is to help better understand the effects of exit face inclinations on critical gradients. This will lead to more practical ways to predict critical hydraulic gradients and slope stability using soil properties and exit face conditions.
openaire +3 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source